Alzheimer's Disease (AD) is the leading cause of dementia, observed at a higher incidence
in women compared with men. Treatments aimed at improving pathology in AD remain …

Psychological stress has a pervasive influence on our lives. In many cases adapting to
stress strengthens organisms, but chronic or severe stress is usually harmful. One surprising …

Various stressors may disrupt the redox homeostasis of an organism by causing oxidative
and nitrosative stress that may activate stressor-specific pathways and provoke specific …

Social interaction plays an essential role in species survival for socialized animals. Previous
studies have shown that a lack of social interaction such as social isolation, especially in the …

It is estimated that 40% of dementia cases could be prevented by modification of lifestyle
factors that associate with disease risk. One of these potentially modifiable lifestyle factors is …

Depression is among the most common neuropsychiatric comorbidities in Alzheimer's
disease (AD) and other Tauopathies. Apart from its anti-depressive and anxiolytic effects …

This review describes the role of social isolation in the development of anxiety and
depression-like behavior in rodents. The duration of social isolation, age from onset of social …

Objective During the COVID‐19 pandemic, quarantine and staying at home is advised. The
social relationship between people has become deficient, and human social isolation (SI) …

Polyphenols, a category of plant compounds that contain multiple phenol structural units, are
widely distributed throughout the plant kingdom and have multiple benefits for human health …

Our previous experiments demonstrated that social isolation (SI) caused AD-like tau
hyperphosphorylation and spatial memory deficits in middle-aged rats. However, the …