[HTML][HTML] Role of Vγ9vδ2 T lymphocytes in infectious diseases

L Gay, S Mezouar, C Cano, P Frohna, JL Mège… - Frontiers in …, 2022 - frontiersin.org
The T cell receptor Vγ9Vδ2 T cells bridge innate and adaptive antimicrobial immunity in
primates. These Vγ9Vδ2 T cells respond to phosphoantigens (pAgs) present in microbial or …

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

P Ruibal, L Voogd, SA Joosten… - Immunological …, 2021 - Wiley Online Library
Vaccination strategies against mycobacteria, focusing mostly on classical T‐and B‐cells,
have shown limited success, encouraging the addition of alternative targets. Classically …

TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity

J Bi, C Cheng, C Zheng, C Huang, X Zheng, X Wan… - Science …, 2021 - science.org
The maturation process of NK cells determines their functionality during which IL-15 plays a
critical role. However, very few checkpoints specifically targeting this process have been …

[HTML][HTML] Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor repertoire in cell culture

AE Linti, TW Göbel, SP Früh - Frontiers in Immunology, 2024 - frontiersin.org
In chickens, γδ T cells represent a large fraction of peripheral T cells; however, their function
remains largely unknown. Here, we describe the selective in vitro expansion of γδ T cells …

[HTML][HTML] Vγ2 x PD-L1, a bispecific antibody targeting both the Vγ2 TCR and PD-L1, improves the anti-tumor response of Vγ2Vδ2 T cell

R Yang, Q He, H Zhou, C Gong, X Wang… - Frontiers in …, 2022 - frontiersin.org
The potent cytotoxic property of Vγ2Vδ2 T cells makes them attractive for adoptive T cell
transfer therapy. The transfusing of the expanded Vγ2Vδ2 T cells into cancer patients shows …

Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism

M Dragan, Z Chen, Y Li, J Le, P Sun, D Haensel… - EMBO …, 2023 - embopress.org
Skin epidermis constitutes the outer permeability barrier that protects the body from
dehydration, heat loss, and myriad external assaults. Mechanisms that maintain barrier …

[HTML][HTML] SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or γδ T cells

K Singh, S Cogan, S Elekes, DM Murphy, S Cummins… - Plos one, 2022 - journals.plos.org
γδ T cells are thought to contribute to immunity against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), but the mechanisms by which they are activated by the virus …

[HTML][HTML] Genetics and functional mechanisms of STAT3 polymorphisms in human tuberculosis

F Wang, G Huang, L Shen, Y Peng, W Sha… - Frontiers in Cellular …, 2021 - frontiersin.org
Signal transducer and activator of transcription-3 (STAT3) plays an important role in
biological balance. Our and others previous studies implied that STAT3 had a great effect on …

Fast‐acting γδ T‐cell subpopulation and protective immunity against infections

L Shen, D Huang, A Qaqish, J Frencher… - Immunological …, 2020 - Wiley Online Library
Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non‐human primates, account
for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T …

Adjunctive Zoledronate+ IL-2 administrations enhance anti-tuberculosis Vγ2Vδ2 T-effector populations, and improve treatment outcome of multidrug-resistant …

H Shen, E Yang, M Guo, R Yang, G Huang… - Emerging Microbes & …, 2022 - Taylor & Francis
Multidrug-resistant tuberculosis (MDR-TB) is a refractory disease with high mortality rate due
to no or few choices of antibiotics. Adjunctive immunotherapy may help improve treatment …