[HTML][HTML] Role of Vγ9vδ2 T lymphocytes in infectious diseases
L Gay, S Mezouar, C Cano, P Frohna, JL Mège… - Frontiers in …, 2022 - frontiersin.org
The T cell receptor Vγ9Vδ2 T cells bridge innate and adaptive antimicrobial immunity in
primates. These Vγ9Vδ2 T cells respond to phosphoantigens (pAgs) present in microbial or …
primates. These Vγ9Vδ2 T cells respond to phosphoantigens (pAgs) present in microbial or …
The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity
P Ruibal, L Voogd, SA Joosten… - Immunological …, 2021 - Wiley Online Library
Vaccination strategies against mycobacteria, focusing mostly on classical T‐and B‐cells,
have shown limited success, encouraging the addition of alternative targets. Classically …
have shown limited success, encouraging the addition of alternative targets. Classically …
TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity
The maturation process of NK cells determines their functionality during which IL-15 plays a
critical role. However, very few checkpoints specifically targeting this process have been …
critical role. However, very few checkpoints specifically targeting this process have been …
[HTML][HTML] Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor repertoire in cell culture
AE Linti, TW Göbel, SP Früh - Frontiers in Immunology, 2024 - frontiersin.org
In chickens, γδ T cells represent a large fraction of peripheral T cells; however, their function
remains largely unknown. Here, we describe the selective in vitro expansion of γδ T cells …
remains largely unknown. Here, we describe the selective in vitro expansion of γδ T cells …
[HTML][HTML] Vγ2 x PD-L1, a bispecific antibody targeting both the Vγ2 TCR and PD-L1, improves the anti-tumor response of Vγ2Vδ2 T cell
R Yang, Q He, H Zhou, C Gong, X Wang… - Frontiers in …, 2022 - frontiersin.org
The potent cytotoxic property of Vγ2Vδ2 T cells makes them attractive for adoptive T cell
transfer therapy. The transfusing of the expanded Vγ2Vδ2 T cells into cancer patients shows …
transfer therapy. The transfusing of the expanded Vγ2Vδ2 T cells into cancer patients shows …
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism
Skin epidermis constitutes the outer permeability barrier that protects the body from
dehydration, heat loss, and myriad external assaults. Mechanisms that maintain barrier …
dehydration, heat loss, and myriad external assaults. Mechanisms that maintain barrier …
[HTML][HTML] SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or γδ T cells
K Singh, S Cogan, S Elekes, DM Murphy, S Cummins… - Plos one, 2022 - journals.plos.org
γδ T cells are thought to contribute to immunity against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), but the mechanisms by which they are activated by the virus …
coronavirus 2 (SARS-CoV-2), but the mechanisms by which they are activated by the virus …
[HTML][HTML] Genetics and functional mechanisms of STAT3 polymorphisms in human tuberculosis
F Wang, G Huang, L Shen, Y Peng, W Sha… - Frontiers in Cellular …, 2021 - frontiersin.org
Signal transducer and activator of transcription-3 (STAT3) plays an important role in
biological balance. Our and others previous studies implied that STAT3 had a great effect on …
biological balance. Our and others previous studies implied that STAT3 had a great effect on …
Fast‐acting γδ T‐cell subpopulation and protective immunity against infections
L Shen, D Huang, A Qaqish, J Frencher… - Immunological …, 2020 - Wiley Online Library
Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non‐human primates, account
for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T …
for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T …
Adjunctive Zoledronate+ IL-2 administrations enhance anti-tuberculosis Vγ2Vδ2 T-effector populations, and improve treatment outcome of multidrug-resistant …
H Shen, E Yang, M Guo, R Yang, G Huang… - Emerging Microbes & …, 2022 - Taylor & Francis
Multidrug-resistant tuberculosis (MDR-TB) is a refractory disease with high mortality rate due
to no or few choices of antibiotics. Adjunctive immunotherapy may help improve treatment …
to no or few choices of antibiotics. Adjunctive immunotherapy may help improve treatment …