Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed,
primitive hematopoietic progenitor cells. It involves myeloid, monocytic, erythroid …

Chronic myelogenous leukemia is a myeloproliferative disorder. It is characterized by a
biphasic or triphasic clinical course in which a benign chronic phase is followed by …

Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome
(Ph), resulting from a reciprocal translocation between chromosomes 9 and 22 [t (9; 22] that …

For the diagnosis of CML and for monitoring of treatment response the detection of the t (9;
22)(q34; q11) or the BCR-ABL rearrangement is necessary. Chromosome banding analysis …

Background Vascular endothelial cells lost from the bloodvessel endothelium through
necrosis or apoptosis must be replaced. We investigated in a leukaemia model whether …

The prognosis of patients with chronic myelogenous leukemia (CML) has significantly
improved over the last 20 years. Whereas the median survival durations were 4-5 years in …

In chronic myeloid leukemia, different methods are available to monitor the response to
therapy: chromosome banding analysis (CBA), interphase fluorescence in situ hybridization …

The degree of tumor load reduction after therapy is an important prognostic factor for
patients with CML. Conventional metaphase analysis has been considered to be the 'gold …

Presents information on a study which examined the developments in fluorescence in situ
hybridization (FISH), and its impact on the cytogenetic diagnosis and hematological …

Chronic myeloid leukemia provides an illustrative disease model for both molecular
pathogenesis of cancer and rational drug therapy. Chronic myeloid leukemia is a clonal …