A high percentage of patients with leukemia, lymphoma, and solid tumors achieve a
complete clinical remission after initial treatment, but the majority of these patients will finally …

The elucidation of the triggering molecular mechanism of chronic myeloid leukemia gave
rise to the development of imatinib, a tyrosine kinase inhibitor and a prototype of target …

The reverse transcriptase‐polymerase chain reaction (RT‐PCR) was compared with
fluorescence in situ hybridization (FISH) and real‐time quantitative RT‐PCR (RQ‐PCR) for …

Chronic myeloid leukemia (CML) is a stem cell disease characterized by excessive
accumulation of clonal myeloid (precursor) cells in hematopoietic tissues. CML cells display …

In order to analyze the efficiency of interphase FISH for the detection and monitoring of Ph+
cells in chronic myelogenous leukemia (CML) under interferon (IFN) treatment, the following …

The molecular signature of BCR-ABL fusion in chronic myeloid leukemia (CML) provides a
unique tool for diagnosis and monitoring of tumor burden during therapy. The gold standard …

(57) ABSTRACT A method of detecting reciprocal gene translocations by employing multiple
probe sets which span the breakpoint regions and encompass regions on both sides of each …

This chapter deals with the application of fluorescence in situ hybridization (FISH) to study
interphase nuclei from patients with chronic myeloid leukemia (CML). In our experience …

WT1 has been implicated in human leukemia and hematopoiesis, but its role in stem cell
differentiation is not yet fully defined. We show that Wt1-null murine fetal liver cells are …

In this volume, an international team of experts in chronic myeloid leukemia share their
expertise. In particular, they contribute their insights on the latest advances in understanding …