Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …

Preventive approaches have latterly gained traction for improving mental health in young
people. In this paper, we first appraise the conceptual foundations of preventive psychiatry …

Importance Detection, prognosis, and indicated interventions in individuals at clinical high
risk for psychosis (CHR-P) are key components of preventive psychiatry. Objective To …

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …

Background Prenatal and perinatal insults are implicated in the aetiopathogenesis of
psychotic disorders but the consistency and magnitude of their associations with psychosis …

Promotion of good mental health in young people with and without mental disorders has
received little empirical research attention and interventions for improving mental health in …

The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

Psychosis is a heterogeneous psychiatric condition for which a multitude of risk and
protective factors have been suggested. This umbrella review aimed to classify the strength …

Outcomes of psychotic disorders are associated with high personal, familiar, societal and
clinical burden. There is thus an urgent clinical and societal need for improving those …