[HTML][HTML] Targeting KRAS mutant cancers: from druggable therapy to drug resistance

C Zhu, X Guan, X Zhang, X Luan, Z Song, X Cheng… - Molecular cancer, 2022 - Springer
Abstract Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently
mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with …

[HTML][HTML] Towards personalized, tumour-specific, therapeutic vaccines for cancer

Z Hu, PA Ott, CJ Wu - Nature Reviews Immunology, 2018 - nature.com
Cancer vaccines, which are designed to amplify tumour-specific T cell responses through
active immunization, have long been envisioned as a key tool of effective cancer …

Antitumour dendritic cell vaccination in a priming and boosting approach

A Harari, M Graciotti, M Bassani-Sternberg… - Nature Reviews Drug …, 2020 - nature.com
Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …

The emergence and evolution of borophene

M Ou, X Wang, L Yu, C Liu, W Tao, X Ji… - Advanced …, 2021 - Wiley Online Library
Neighboring carbon and sandwiched between non‐metals and metals in the periodic table
of the elements, boron is one of the most chemically and physically versatile elements, and …

[HTML][HTML] Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

WL Liu, MZ Zou, T Liu, JY Zeng, X Li, WY Yu… - Nature …, 2019 - nature.com
Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using
exogenous antigens and adoptive cells, we show a concept of utilizing biologically …

Peptide-based supramolecular hydrogels for local drug delivery

Z Zhang, S Ai, Z Yang, X Li - Advanced Drug Delivery Reviews, 2021 - Elsevier
Peptide-based supramolecular hydrogels have shown great promise as drug delivery
systems (DDSs) because of their excellent biocompatibility, biodegradability, biological …

Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses

Q Chen, M Chen, Z Liu - Chemical Society Reviews, 2019 - pubs.rsc.org
Cancer immunotherapy by educating or stimulating patients' own immune systems to attack
cancer cells has demonstrated promising therapeutic responses in the clinic. However …

[HTML][HTML] The urgent need to recover MHC class I in cancers for effective immunotherapy

F Garrido, N Aptsiauri, EM Doorduijn, AMG Lora… - Current opinion in …, 2016 - Elsevier
Highlights•Tumor immune escape compromises the efficacy of cancer immunotherapy.•Loss
of MHC class I expression is a frequent event in cancer cells.•Three tumor phenotypes …

Cancer vaccines: toward the next breakthrough in cancer immunotherapy

Y Igarashi, T Sasada - Journal of immunology research, 2020 - Wiley Online Library
Until now, three types of well‐recognized cancer treatments have been developed, ie,
surgery, chemotherapy, and radiotherapy; these either remove or directly attack the cancer …

Dendritic cell–based cancer vaccines

PM Santos, LH Butterfield - The Journal of Immunology, 2018 - journals.aai.org
Dendritic cells (DC) are specialized immune cells that play a critical role in promoting an
immune response against Ags, which can include foreign pathogenic Ags and self-tumor …