[HTML][HTML] Targeting KRAS mutant cancers: from druggable therapy to drug resistance
C Zhu, X Guan, X Zhang, X Luan, Z Song, X Cheng… - Molecular cancer, 2022 - Springer
Abstract Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently
mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with …
mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with …
[HTML][HTML] Towards personalized, tumour-specific, therapeutic vaccines for cancer
Z Hu, PA Ott, CJ Wu - Nature Reviews Immunology, 2018 - nature.com
Cancer vaccines, which are designed to amplify tumour-specific T cell responses through
active immunization, have long been envisioned as a key tool of effective cancer …
active immunization, have long been envisioned as a key tool of effective cancer …
Antitumour dendritic cell vaccination in a priming and boosting approach
A Harari, M Graciotti, M Bassani-Sternberg… - Nature Reviews Drug …, 2020 - nature.com
Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …
anticancer strategy but has not yet provided robust clinical benefits in large patient …
The emergence and evolution of borophene
Neighboring carbon and sandwiched between non‐metals and metals in the periodic table
of the elements, boron is one of the most chemically and physically versatile elements, and …
of the elements, boron is one of the most chemically and physically versatile elements, and …
[HTML][HTML] Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using
exogenous antigens and adoptive cells, we show a concept of utilizing biologically …
exogenous antigens and adoptive cells, we show a concept of utilizing biologically …
Peptide-based supramolecular hydrogels for local drug delivery
Z Zhang, S Ai, Z Yang, X Li - Advanced Drug Delivery Reviews, 2021 - Elsevier
Peptide-based supramolecular hydrogels have shown great promise as drug delivery
systems (DDSs) because of their excellent biocompatibility, biodegradability, biological …
systems (DDSs) because of their excellent biocompatibility, biodegradability, biological …
Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses
Cancer immunotherapy by educating or stimulating patients' own immune systems to attack
cancer cells has demonstrated promising therapeutic responses in the clinic. However …
cancer cells has demonstrated promising therapeutic responses in the clinic. However …
[HTML][HTML] The urgent need to recover MHC class I in cancers for effective immunotherapy
Highlights•Tumor immune escape compromises the efficacy of cancer immunotherapy.•Loss
of MHC class I expression is a frequent event in cancer cells.•Three tumor phenotypes …
of MHC class I expression is a frequent event in cancer cells.•Three tumor phenotypes …
Cancer vaccines: toward the next breakthrough in cancer immunotherapy
Y Igarashi, T Sasada - Journal of immunology research, 2020 - Wiley Online Library
Until now, three types of well‐recognized cancer treatments have been developed, ie,
surgery, chemotherapy, and radiotherapy; these either remove or directly attack the cancer …
surgery, chemotherapy, and radiotherapy; these either remove or directly attack the cancer …
Dendritic cell–based cancer vaccines
PM Santos, LH Butterfield - The Journal of Immunology, 2018 - journals.aai.org
Dendritic cells (DC) are specialized immune cells that play a critical role in promoting an
immune response against Ags, which can include foreign pathogenic Ags and self-tumor …
immune response against Ags, which can include foreign pathogenic Ags and self-tumor …