Insulin signaling controls cell growth and metabolic homeostasis. Dysregulation of this
pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have …

Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …

Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it
controls the correct segregation of chromosomes during mitosis. Many studies have focused …

Protein machines are multi-subunit protein complexes that orchestrate highly regulated
biochemical tasks. An example is the anaphase-promoting complex/cyclosome (APC/C), a …

Abstract The Anaphase-Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase,
and two co-activators, Cdc20 and Cdh1, enable the ubiquitin-dependent proteasomal …

The ubiquitin-proteasome system (UPS) promotes the timely degradation of short-lived
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …

The balance between cell cycle progression and apoptosis is important for both surveillance
against genomic defects and responses to drugs that arrest the cell cycle. In this report, we …

RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

Microtubule inhibitors are important cancer drugs that induce mitotic arrest by activating the
spindle assembly checkpoint (SAC), which, in turn, inhibits the ubiquitin ligase activity of the …

The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to
cell division known as the cell cycle. Not only does ubiquitin-mediated proteolysis constitute …