Although chemotherapy can improve the overall survival and prognosis of cancer patients,
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Inactivating STK11/LKB1 mutations are genomic drivers of primary resistance to
immunotherapy in KRAS-mutated lung adenocarcinoma (LUAD), although the underlying …

Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

The role of metabolites exchanged in the tumor microenvironment is largely thought of as
fuels to drive the increased biosynthetic and bioenergetic demands of growing tumors …

Energy production by cancer is driven by accelerated glycolysis, independently of oxygen
levels, which results in increased lactate production. Lactate is shuttled to and from cancer …

Uveal melanoma (UM), the most common primary intraocular cancer in adults, is among the
tumors with poorer prognosis. Recently, the role of the oncometabolite lactate has become …

Malignant tumors exhibit rapid growth and high metabolic rates, similar to embryonic stem
cells, and depend on aerobic glycolysis, known as the “Warburg effect”. This understanding …

Cancer metabolic reprogramming is a complex process that provides malignant cells with
selective advantages to grow and propagate in the hostile environment created by the …

Purpose Transcription factor zinc finger E-box binding homeobox 1 (ZEB1) was well-known
as a transcription factor in epithelial-mesenchymal transition (EMT) process of cancer, but …