The mechanism of Warburg effect-induced chemoresistance in cancer
C Liu, Y Jin, Z Fan - Frontiers in oncology, 2021 - frontiersin.org
Although chemotherapy can improve the overall survival and prognosis of cancer patients,
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …
Targeting monocarboxylate transporters (MCTs) in cancer: how close are we to the clinics?
As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …
causing an excess production of lactate along with an increase in extracellular acidity …
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
Inactivating STK11/LKB1 mutations are genomic drivers of primary resistance to
immunotherapy in KRAS-mutated lung adenocarcinoma (LUAD), although the underlying …
immunotherapy in KRAS-mutated lung adenocarcinoma (LUAD), although the underlying …
Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer
Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …
the world. The emerging field of cardio-oncology has revealed that these seemingly …
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment
The role of metabolites exchanged in the tumor microenvironment is largely thought of as
fuels to drive the increased biosynthetic and bioenergetic demands of growing tumors …
fuels to drive the increased biosynthetic and bioenergetic demands of growing tumors …
Prognostic value of monocarboxylate transporter 1 overexpression in cancer: a systematic review
A Silva, MC Cerqueira, B Rosa, C Sobral… - International Journal of …, 2023 - mdpi.com
Energy production by cancer is driven by accelerated glycolysis, independently of oxygen
levels, which results in increased lactate production. Lactate is shuttled to and from cancer …
levels, which results in increased lactate production. Lactate is shuttled to and from cancer …
Lactate rewrites the metabolic reprogramming of uveal melanoma cells and induces quiescence phenotype
L Longhitano, S Giallongo, L Orlando, G Broggi… - International Journal of …, 2022 - mdpi.com
Uveal melanoma (UM), the most common primary intraocular cancer in adults, is among the
tumors with poorer prognosis. Recently, the role of the oncometabolite lactate has become …
tumors with poorer prognosis. Recently, the role of the oncometabolite lactate has become …
Metabolic interplay in the tumor microenvironment: implications for immune function and anticancer response
Malignant tumors exhibit rapid growth and high metabolic rates, similar to embryonic stem
cells, and depend on aerobic glycolysis, known as the “Warburg effect”. This understanding …
cells, and depend on aerobic glycolysis, known as the “Warburg effect”. This understanding …
Phytochemicals target multiple metabolic pathways in cancer
O Shuvalov, Y Kirdeeva, A Daks, O Fedorova… - Antioxidants, 2023 - mdpi.com
Cancer metabolic reprogramming is a complex process that provides malignant cells with
selective advantages to grow and propagate in the hostile environment created by the …
selective advantages to grow and propagate in the hostile environment created by the …
ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer
X Han, Y Long, X Duan, Z Liu, X Hu, J Zhou, N Li… - Experimental Cell …, 2022 - Elsevier
Purpose Transcription factor zinc finger E-box binding homeobox 1 (ZEB1) was well-known
as a transcription factor in epithelial-mesenchymal transition (EMT) process of cancer, but …
as a transcription factor in epithelial-mesenchymal transition (EMT) process of cancer, but …