Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

Randomized trial of anticoagulation strategies for noncritically ill patients hospitalized with COVID-19

GW Stone, ME Farkouh, A Lala, E Tinuoye… - Journal of the American …, 2023 - jacc.org
Background Prior studies of therapeutic-dose anticoagulation in patients with COVID-19
have reported conflicting results. Objectives We sought to determine the safety and …

[HTML][HTML] S1-leitlinie long-/post-COVID

AR Koczulla, T Ankermann, U Behrends, P Berlit… - …, 2022 - thieme-connect.com
Die Deutsche Gesellschaft für Pneumologie hat 2021 die AWMF S1-Leitlinie Long-/Post-
COVID initiiert. In einem breiten interdisziplinären Ansatz wurde diese S1-Leitlinie …

NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis

N Potere, E Garrad, Y Kanthi, M Di Nisio… - Cardiovascular …, 2023 - academic.oup.com
Immunothrombosis—immune-mediated activation of coagulation—is protective against
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …

COVID-19-associated pulmonary embolism: review of the pathophysiology, epidemiology, prevention, diagnosis, and treatment

L Ortega-Paz, AH Talasaz… - … in thrombosis and …, 2022 - thieme-connect.com
COVID-19 is associated with endothelial activation in the setting of a potent inflammatory
reaction and a hypercoagulable state. The end result of this thromboinflammatory state is an …

Novel tissue factor inhibition for Thromboprophylaxis in COVID-19: primary results of the ASPEN-COVID-19 Trial

CN Hess, J Hsia, IA Carroll, MR Nehler… - … and Vascular Biology, 2023 - Am Heart Assoc
BACKGROUND: Thrombo-inflammation is central to COVID-19-associated coagulopathy. TF
(tissue factor), a driver of disordered coagulation and inflammation in viral infections, may be …

In situ pulmonary arterial thrombosis: Literature review and clinical significance of a distinct entity

L Baranga, S Khanuja, JA Scott… - American Journal of …, 2023 - Am Roentgen Ray Soc
Please see the Editorial Comment by Andetta Hunsaker discussing this article. Filling
defects identified in the pulmonary arterial tree are commonly presumed to represent an …

Sequelae of long COVID, known and unknown: A review of updated information

T Asakawa, Q Cai, J Shen, Y Zhang, Y Li, P Chen… - Bioscience …, 2023 - jstage.jst.go.jp
Over three years have passed since the COVID-19 pandemic started. The dangerousness
and impact of COVID-19 should definitely not be ignored or underestimated. Other than the …

Prevalence of acute neurological complications and pathological neuroimaging findings in critically ill COVID-19 patients with and without VV-ECMO treatment

A Ippolito, H Urban, K Ghoroghi, N Rosbach… - Scientific Reports, 2022 - nature.com
Acute brain injuries such as intracerebral hemorrhage (ICH) and ischemic stroke have been
reported in critically ill COVID-19 patients as well as in patients treated with veno-venous …