Digital droplet PCR (ddPCR) is a recent version of quantitative PCR (QT-PCR), useful for
measuring gene expression, doing clonality assays and detecting hot spot mutations. In …

Despite the success of BCR‐ABL‐specific tyrosine kinase inhibitors (TKIs) such as imatinib
in chronic phase (CP) chronic myeloid leukaemia (CML), patients with blast phase (BP) …

In this provocative commentary, we consider several questions posed by the late chronic
myeloid leukaemia (CML) expert Prof. Michele Baccarani, which he challenged us to …

Simple Summary This review explores the use of hematopoietic stem cell transplantation
(HSCT) as a treatment option for chronic myeloid leukemia (CML) patients. While CML …

Opinion Statement The introduction of TKIs into the therapeutic armamentarium of CML has
changed the disease paradigm, increasing long-term survival from 20% to over 80%, with a …

Tyrosine kinase inhibitors (TKIs) approved for chronic myeloid leukemia known to have
similar efficacies but different safety profiles. Therefore, the choice of patient-specific …

Background Imatinib, dasatinib, and nilotinib are tyrosine kinase inhibitors (TKIs) approved
in Italy for frontline treatment of chronic‐phase chronic myeloid leukemia (CP‐CML). The …

1Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, 2Faculty of
Medicine, University of Southampton, Southampton, 3Haematopathology & Oncology …

Second-generation tyrosine kinase inhibitors (2GTKI) are more effective in inducing rapid
molecular responses than imatinib when used first-line in patients with chronic myeloid …

Abstract Purpose of Review Chronic myelogenous leukemia (CML) is rare in children,
requiring extrapolation from treatment of adults. In this review, we explore similarities and …