Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach

S Pulakuntla, KB Lokhande, P Padmavathi, M Pal… - VirusDisease, 2021 - Springer
Abstract The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) is
spreading, as the causative pathogen of coronavirus disease-19 (COVID-19). It has infected …

Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis

J Liu, Q Chen, S Liu, X Yang, Y Zhang, F Huang - Life sciences, 2018 - Elsevier
Aims Acute respiratory distress syndrome (ARDS), one of the serious form of acute lung
injury (ALI), is the primary cause of death in patients with ALI. Sini decoction (SND) is a …

Angiotensin (1–7) inhibits arecoline‐induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation

Y You, Y Huang, D Wang, Y Li, G Wang… - Journal of cellular …, 2019 - Wiley Online Library
Arecoline induces oral submucous fibrosis (OSF) via promoting the reactive oxygen species
(ROS). Angiotensin (1–7)(Ang‐(1–7)) protects against fibrosis by counteracting angiotensin …

Angiotensin‐converting enzyme 2 antagonizes angiotensin II‐induced pressor response and NADPH oxidase activation in Wistar–Kyoto rats and spontaneously …

J Lo, VB Patel, Z Wang, J Levasseur… - Experimental …, 2013 - Wiley Online Library
New Findings• What is the central question of this study? Angiotensin‐converting enzyme 2
(ACE2), an enzyme which converts angiotensin II (Ang II) into angiotensin‐(1–7)[Ang‐(1–7)] …

Angiotensin converting enzyme 2: a new important player in the regulation of glycemia

KH Chhabra, H Chodavarapu, E Lazartigues - IUBMB life, 2013 - Wiley Online Library
In spite of the novel antidiabetic drugs available on the market, type 2 diabetes mellitus
(T2DM) affects nearly 25 million people in the USA and causes about 5% of all deaths …

Cerebroprotective action of angiotensin peptides in stroke

RW Regenhardt, DM Bennion, C Sumners - Clinical science, 2014 - portlandpress.com
The goal of the present review is to examine the evidence for beneficial actions of
manipulation of the RAS (renin–angiotensin system) in stroke, with particular focus on Ang …

[HTML][HTML] Perspectives for the use of therapeutic Botulinum toxin as a multifaceted candidate drug to attenuate COVID-19

M Kandasamy - Medicine in Drug Discovery, 2020 - Elsevier
The recent outbreak of coronavirus disease (COVID-19) resulting from a distinctive severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to evolve in many …

Deleterious effects of viral pneumonia on cardiovascular system

J Duan, Y Wu, C Liu, C Yang, L Yang - European heart journal, 2020 - academic.oup.com
Viral pneumonia has a significant effect on the cardiovascular system through various
mechanisms; even though it is traditionally regarded as a pulmonary disease characterized …

Challenge of post-COVID era: management of cardiovascular complications in asymptomatic carriers of SARS-CoV-2

S Gupta, A Mitra - Heart failure reviews, 2022 - Springer
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a highly
pathogenic member of family coronaviridae, has caused an exponentially growing global …

Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice

KH Chhabra, H Xia, KB Pedersen… - American journal …, 2013 - journals.physiology.org
An overactive renin-angiotensin system (RAS) is known to contribute to type 2 diabetes
mellitus (T2DM). Although ACE2 overexpression has been shown to be protective against …