Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Functional gastrointestinal disorders—recently renamed into disorders of gut–brain
interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent …

Proteases are an evolutionarily conserved family of enzymes that degrade peptide bonds
and have been implicated in several common gastrointestinal (GI) diseases. Although …

Aspirin-related gastrointestinal damage is of growing concern. Aspirin use modulates the gut
microbiota and associated metabolites, such as bile acids (BAs), but how this impacts …

The human gut microbiome is a complex microbial community that is strongly linked to both
host health and disease. However, the detailed molecular mechanisms underlying the …

Post‐infectious irritable bowel syndrome (PI‐IBS) occurs after acute infectious diarrhea, and
dysbiosis can be involved in its pathogenesis. Here, the role of chlorogenic acid (CGA) is …

Diet is an important determinant of health and consequently is often implicated in the
development of disease, particularly gastrointestinal (GI) diseases, given the high …

Hormones and neurotransmitters are essential to homeostasis, and their disruptions are
connected to diseases ranging from cancer to anxiety. The differential reactivation of …

Introduction Continuous advances in mass spectrometry (MS) technologies have enabled
deeper and more reproducible proteome characterization and a better understanding of …

Periodontitis is a chronic inflammatory disease associated with persistent oral microbial
dysbiosis. The human β-glucuronidase (GUS) degrades constituents of the periodontium …