Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti …

SA Antar, MA Saleh, AA Al-Karmalawy - Life Sciences, 2022 - Elsevier
Pirfenidone (PFD) is a non-peptide synthetic chemical that inhibits the production of
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …

Recent advances in small-molecular therapeutics for COVID-19

L Zhong, Z Zhao, X Peng, J Zou… - Precision Clinical …, 2022 - academic.oup.com
The COVID-19 pandemic poses a fundamental challenge to global health. Since the
outbreak of SARS-CoV-2, great efforts have been made to identify antiviral strategies and …

Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS …

M Elagawany, AA Elmaaty, A Mostafa… - Journal of enzyme …, 2022 - Taylor & Francis
The global outbreak of the COVID-19 pandemic provokes scientists to make a prompt
development of new effective therapeutic interventions for the battle against SARS-CoV-2. A …

Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in …

AA Al-Karmalawy, DS El-Gamil… - Journal of enzyme …, 2023 - Taylor & Francis
In this article, emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-
carboxamido derivatives (3a–3g) in an attempt to improve their biological availability and …

Evaluation of the mutagenic effects of Molnupiravir and N4‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing

JA Miranda, PB McKinzie… - Environmental and …, 2022 - Wiley Online Library
Molnupiravir (MOV) is used to treat COVID‐19. In cells, MOV is converted to the
ribonucleoside analog N4‐hydroxycytidine (NHC) and incorporated into the SARS‐CoV‐2 …

[HTML][HTML] Structural characteristics of heparin binding to SARS-CoV-2 spike protein RBD of Omicron sub-lineages BA. 2.12. 1, BA. 4 and BA. 5

D Shi, C Bu, P He, Y Song, JS Dordick, RJ Linhardt… - Viruses, 2022 - mdpi.com
The now prevalent Omicron variant and its subvariants/sub-lineages have led to a significant
increase in COVID-19 cases and raised serious concerns about increased risk of infectivity …

VV116 as a potential treatment for COVID-19

MW McCarthy - Expert Opinion on Pharmacotherapy, 2023 - Taylor & Francis
Introduction VV116 is a chemically-modified version of the antiviral remdesivir with oral
bioavailability and potent activity against SARS-CoV-2. Areas Covered The optimal …

[HTML][HTML] Identification of possible SARS-CoV-2 main protease inhibitors: in silico molecular docking and dynamic simulation studies

A Mukherjee, KM Pandey, KK Ojha… - Beni-Suef University …, 2023 - Springer
Background COVID-19 was declared a pandemic by the World Health Organisation in 2020
after its outbreak in December 2019 in Wuhan, China. Since researchers have been working …

[HTML][HTML] Sulfated liposome-based artificial cell membrane glycocalyx nanodecoys for coronavirus inactivation by membrane fusion

X Li, N Cheng, D Shi, Y Li, C Li, M Zhu, Q Jin, Z Wu… - Bioactive Materials, 2024 - Elsevier
As a broad-spectrum antiviral nanoparticle, the cell membrane nanodecoy is a promising
strategy for preventing viral infections. However, most of the cell membrane nanodecoys can …

[HTML][HTML] Indole-based compounds as potential drug candidates for SARS-CoV-2

AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …