Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer
J Gu, W Huang, X Wang, J Zhang, T Tao, Y Zheng… - Molecular Cancer, 2022 - Springer
Background Although gemcitabine has been considered as the first-line drug for advanced
pancreatic cancer (PC), development of resistance to gemcitabine severely limits the …
pancreatic cancer (PC), development of resistance to gemcitabine severely limits the …
Exosomes and their role in tumorigenesis and anticancer drug resistance
N Milman, L Ginini, Z Gil - Drug Resistance Updates, 2019 - Elsevier
Exosomes are a class of extracellular vesicles ranging in size from 40 to 100 nm, which are
secreted by both cancer cells and multiple stromal cells in the tumor microenvironment …
secreted by both cancer cells and multiple stromal cells in the tumor microenvironment …
Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising …
Background: Chemoresistance is a significant clinical problem in pancreatic cancer (PC)
and underlying molecular mechanisms still remain to be completely understood. Here we …
and underlying molecular mechanisms still remain to be completely understood. Here we …
[HTML][HTML] Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
CY Lan, SY Chen, CW Kuo, CC Lu, GC Yen - Journal of food and drug …, 2019 - Elsevier
The triggering of gemcitabine (GEM) drug resistance in pancreatic cancer by the receptor for
advanced glycation end products (RAGE) has been demonstrated. Hence, finding a safe …
advanced glycation end products (RAGE) has been demonstrated. Hence, finding a safe …
CircRNAs in anticancer drug resistance: recent advances and future potential
T Xu, M Wang, L Jiang, L Ma, L Wan, Q Chen, C Wei… - Molecular cancer, 2020 - Springer
CircRNAs are a novel class of RNA molecules with a unique closed continuous loop
structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue …
structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue …
PTEN deficiency facilitates gemcitabine efficacy in cancer by modulating the phosphorylation of PP2Ac and DCK
TY Jiang, XW Cui, TM Zeng, YF Pan, YK Lin… - Science Translational …, 2023 - science.org
Gemcitabine is a nucleoside analog that has been successfully used in the treatment of
multiple cancers. However, intrinsic or acquired resistance reduces the chemotherapeutic …
multiple cancers. However, intrinsic or acquired resistance reduces the chemotherapeutic …
Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs
W Jiang, J Xia, S Xie, R Zou, S Pan, Z Wang… - Drug Resistance …, 2020 - Elsevier
Chemoresistance including intrinsic and acquired anticancer drug resistance continues to
be a primary hindrance towards curative cancer treatment. Therefore, deciphering the …
be a primary hindrance towards curative cancer treatment. Therefore, deciphering the …
[HTML][HTML] Inhibiting RRM2 to enhance the anticancer activity of chemotherapy
Y Zhan, L Jiang, X Jin, S Ying, Z Wu, L Wang… - Biomedicine & …, 2021 - Elsevier
RRM2, the small subunit of ribonucleotide reductase, is identified as a tumor promotor and
therapeutic target. It is common to see the overexpression of RRM2 in chemo-resistant …
therapeutic target. It is common to see the overexpression of RRM2 in chemo-resistant …
[HTML][HTML] GSK3β as a novel promising target to overcome chemoresistance in pancreatic cancer
C Pecoraro, B Faggion, B Balboni, D Carbone… - Drug Resistance …, 2021 - Elsevier
Pancreatic cancer is an aggressive malignancy with increasing incidence and poor
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …
Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics
Efficacy of chemotherapy in the treatment of distinct malignancies is often hampered by drug
resistance arising in the tumor. Understanding the molecular basis of drug resistance and …
resistance arising in the tumor. Understanding the molecular basis of drug resistance and …