Smart hypoxia-responsive transformable and charge-reversible nanoparticles for the deep penetration and tumor microenvironment modulation of pancreatic cancer
H Chen, Q Guo, Y Chu, C Li, Y Zhang, P Liu, Z Zhao… - Biomaterials, 2022 - Elsevier
The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the
major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong …
major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong …
Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going
C Liang, S Shi, Q Meng, D Liang, S Ji… - … & molecular medicine, 2017 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human
malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive …
malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive …
[HTML][HTML] Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance
M Capula, M Perán, G Xu, V Donati, D Yee… - Drug Resistance …, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest incidence/death ratios
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …
[HTML][HTML] Advances in pancreatic cancer biomarkers
Biomarkers play an essential role in the management of patients with invasive cancers.
Pancreatic ductal adenocarcinoma (PDC) associated with poor prognosis due to advanced …
Pancreatic ductal adenocarcinoma (PDC) associated with poor prognosis due to advanced …
Ferroptosis: At the crossroad of gemcitabine resistance and tumorigenesis in pancreatic cancer
J Yang, J Xu, B Zhang, Z Tan, Q Meng, J Hua… - International Journal of …, 2021 - mdpi.com
The overall five-year survival rate of pancreatic cancer has hardly changed in the past few
decades (less than 10%) because of resistance to all known therapies, including …
decades (less than 10%) because of resistance to all known therapies, including …
Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer
G Xiong, C Liu, G Yang, M Feng, J Xu, F Zhao… - Journal of hematology & …, 2019 - Springer
Background Chemoresistance is one of the main causes of poor prognosis in pancreatic
cancer patients. Understanding the mechanisms implicated in chemoresistance of …
cancer patients. Understanding the mechanisms implicated in chemoresistance of …
Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance
S Jiang, T Deng, H Cheng, W Liu, D Shi, J Yuan… - Journal of Experimental …, 2023 - Springer
Background Gemcitabine resistance (GR) is a significant clinical challenge in pancreatic
adenocarcinoma (PAAD) treatment. Macrophages in the tumor immune-microenvironment …
adenocarcinoma (PAAD) treatment. Macrophages in the tumor immune-microenvironment …
[HTML][HTML] 2005-2015 年中国胰腺癌发病与死亡趋势分析
蔡洁， 陈宏达， 卢明， 张愉涵， 陆斌， 由磊， 代敏… - 中华流行病学 …, 2021 - html.rhhz.net
目的分析2005-2015 年中国胰腺癌发病及死亡的趋势并分别估计其年龄-时期-队列效应.
方法基于《 中国肿瘤登记年报》 数据, 利用Joinpoint 回归分析2005-2015 年胰腺癌的发病率及 …
方法基于《 中国肿瘤登记年报》 数据, 利用Joinpoint 回归分析2005-2015 年胰腺癌的发病率及 …
Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma
ZW Chen, JF Hu, ZW Wang, CY Liao, FP Kang… - Journal of Experimental …, 2022 - Springer
Background Chemoresistance of pancreatic cancer is the main reason for the poor treatment
effect of pancreatic cancer patients. Exploring chemotherapy resistance-related genes has …
effect of pancreatic cancer patients. Exploring chemotherapy resistance-related genes has …
The miR-92a-2-5p in exosomes from macrophages increases liver cancer cells invasion via altering the AR/PHLPP/p-AKT/β-catenin signaling
G Liu, X Ouyang, Y Sun, Y Xiao, B You, Y Gao… - Cell Death & …, 2020 - nature.com
Early studies indicated that the androgen receptor (AR) might play important roles in the
regulating of the initiation and progression of hepatocellular carcinoma (HCC), but its …
regulating of the initiation and progression of hepatocellular carcinoma (HCC), but its …