Pathogenic mechanisms associated with different clinical courses of multiple sclerosis
H Lassmann - Frontiers in immunology, 2019 - frontiersin.org
In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …
which may at later times transform into secondary progressive disease (SPMS). In a minority …
Progressive multiple sclerosis: from pathogenic mechanisms to treatment
J Correale, MI Gaitán, MC Ysrraelit, MP Fiol - Brain, 2017 - academic.oup.com
During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …
disease mechanisms have led to the development of several disease-modifying therapies …
Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions
NL Fransen, CC Hsiao, M van der Poel… - Brain, 2020 - academic.oup.com
Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been
suggested that in the progressive late phase, inflammatory lesion activity declines. We …
suggested that in the progressive late phase, inflammatory lesion activity declines. We …
Association between pathological and MRI findings in multiple sclerosis
M Filippi, W Brück, D Chard, F Fazekas… - The Lancet …, 2019 - thelancet.com
Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …
sclerosis that explain disease manifestations, and for guiding the development of new …
Cortical demyelination and diffuse white matter injury in multiple sclerosis
A Kutzelnigg, CF Lucchinetti, C Stadelmann, W Brück… - Brain, 2005 - academic.oup.com
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …
Detection of ectopic B‐cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
B Serafini, B Rosicarelli, R Magliozzi… - Brain …, 2004 - Wiley Online Library
Multiple sclerosis (MS) is characterized by synthesis of oligoclonal immunoglobulins and the
presence of B‐cell clonal expansions in the central nervous system (CNS). Because ectopic …
presence of B‐cell clonal expansions in the central nervous system (CNS). Because ectopic …
Pathology of multiple sclerosis and related inflammatory demyelinating diseases
A Kutzelnigg, H Lassmann - Handbook of clinical neurology, 2014 - Elsevier
This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …
including recent insights into its molecular neuropathology and immunology. It shows that all …
Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis
The primary progressive form of multiple sclerosis is characterized by accrual of
neurological dysfunction from disease onset without remission and it is still a matter of …
neurological dysfunction from disease onset without remission and it is still a matter of …
Primary-progressive multiple sclerosis
DH Miller, SM Leary - The Lancet Neurology, 2007 - thelancet.com
Summary About 10–15% of patients with multiple sclerosis (MS) present with gradually
increasing neurological disability, a disorder known as primary-progressive multiple …
increasing neurological disability, a disorder known as primary-progressive multiple …
In vitro modeling of the neurovascular unit: advances in the field
The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its
functional and structural integrity is vital in maintaining the homeostasis of the brain …
functional and structural integrity is vital in maintaining the homeostasis of the brain …