Pathogenic mechanisms associated with different clinical courses of multiple sclerosis

H Lassmann - Frontiers in immunology, 2019 - frontiersin.org
In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …

Progressive multiple sclerosis: from pathogenic mechanisms to treatment

J Correale, MI Gaitán, MC Ysrraelit, MP Fiol - Brain, 2017 - academic.oup.com
During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

NL Fransen, CC Hsiao, M van der Poel… - Brain, 2020 - academic.oup.com
Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been
suggested that in the progressive late phase, inflammatory lesion activity declines. We …

Association between pathological and MRI findings in multiple sclerosis

M Filippi, W Brück, D Chard, F Fazekas… - The Lancet …, 2019 - thelancet.com
Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

Cortical demyelination and diffuse white matter injury in multiple sclerosis

A Kutzelnigg, CF Lucchinetti, C Stadelmann, W Brück… - Brain, 2005 - academic.oup.com
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …

Detection of ectopic B‐cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis

B Serafini, B Rosicarelli, R Magliozzi… - Brain …, 2004 - Wiley Online Library
Multiple sclerosis (MS) is characterized by synthesis of oligoclonal immunoglobulins and the
presence of B‐cell clonal expansions in the central nervous system (CNS). Because ectopic …

Pathology of multiple sclerosis and related inflammatory demyelinating diseases

A Kutzelnigg, H Lassmann - Handbook of clinical neurology, 2014 - Elsevier
This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

SR Choi, OW Howell, D Carassiti, R Magliozzi… - Brain, 2012 - academic.oup.com
The primary progressive form of multiple sclerosis is characterized by accrual of
neurological dysfunction from disease onset without remission and it is still a matter of …

Primary-progressive multiple sclerosis

DH Miller, SM Leary - The Lancet Neurology, 2007 - thelancet.com
Summary About 10–15% of patients with multiple sclerosis (MS) present with gradually
increasing neurological disability, a disorder known as primary-progressive multiple …

In vitro modeling of the neurovascular unit: advances in the field

A Bhalerao, F Sivandzade, SR Archie… - Fluids and Barriers of …, 2020 - Springer
The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its
functional and structural integrity is vital in maintaining the homeostasis of the brain …