Roles of transposable elements in the regulation of mammalian transcription
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …
contain sequences capable of recruiting the host transcription machinery, which they use to …
Characterizing cis-regulatory elements using single-cell epigenomics
Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
Dynamics of CTCF-and cohesin-mediated chromatin looping revealed by live-cell imaging
Animal genomes are folded into loops and topologically associating domains (TADs) by
CTCF and loop-extruding cohesins, but the live dynamics of loop formation and stability …
CTCF and loop-extruding cohesins, but the live dynamics of loop formation and stability …
Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments
Although enhancers are central regulators of mammalian gene expression, the mechanisms
underlying enhancer–promoter (EP) interactions remain unclear. Chromosome …
underlying enhancer–promoter (EP) interactions remain unclear. Chromosome …
Enhancer–promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness
S Chakraborty, N Kopitchinski, Z Zuo, A Eraso… - Nature …, 2023 - nature.com
How enhancers activate their distal target promoters remains incompletely understood. Here
we dissect how CTCF-mediated loops facilitate and restrict such regulatory interactions …
we dissect how CTCF-mediated loops facilitate and restrict such regulatory interactions …
[HTML][HTML] Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers
The relationships between chromosomal compartmentalization, chromatin state and function
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
Transposable elements in mammalian chromatin organization
Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …
mammalian genomic sequence. TEs are capable of making additional copies of themselves …
scNanoHi-C: a single-cell long-read concatemer sequencing method to reveal high-order chromatin structures within individual cells
The high-order three-dimensional (3D) organization of regulatory genomic elements
provides a topological basis for gene regulation, but it remains unclear how multiple …
provides a topological basis for gene regulation, but it remains unclear how multiple …
CTCF-mediated chromatin looping provides a topological framework for the formation of phase-separated transcriptional condensates
CTCF is crucial to the organization of mammalian genomes into loop structures. According
to recent studies, the transcription apparatus is compartmentalized and concentrated at …
to recent studies, the transcription apparatus is compartmentalized and concentrated at …
[HTML][HTML] Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF
A Aljahani, P Hua, MA Karpinska, K Quililan… - Nature …, 2022 - nature.com
Enhancers and promoters predominantly interact within large-scale topologically
associating domains (TADs), which are formed by loop extrusion mediated by cohesin and …
associating domains (TADs), which are formed by loop extrusion mediated by cohesin and …