Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis

AD O'brien, VL Tesh, A Donohue-Rolfe… - Pathogenesis of …, 1992 - Springer
Dysentery was well known and clearly described in many ancient texts and histories. The
first step towards the description of the genus Shigella, however, was the identification of …

Shiga toxins and stx phages: highly diverse entities

A Krüger, PMA Lucchesi - Microbiology, 2015 - microbiologyresearch.org
Shiga toxins are the main virulence factors of a group of Escherichia coli strains [Shiga toxin-
producing E. coli (STEC)] that cause severe human diseases, such as haemorrhagic colitis …

Sequence of Shiga Toxin 2 Phage 933W fromEscherichia coli O157:H7: Shiga Toxin as a Phage Late-Gene Product

G Plunkett III, DJ Rose, TJ Durfee… - Journal of …, 1999 - Am Soc Microbiol
Lysogenic bacteriophages are major vehicles for the transfer of genetic information between
bacteria, including pathogenicity and/or virulence determinants. In the enteric pathogen …

Shiga-toxin-converting bacteriophages

H Schmidt - Research in microbiology, 2001 - Elsevier
Shiga toxins (Stx) comprise a family of potent cytotoxins that are involved in severe human
disease. Stx are mainly produced by Escherichia coli isolated from human and nonhuman …

Sorbitol-Fermenting Shiga Toxin-Producing Escherichia coli O157:H Strains: Epidemiology, Phenotypic and Molecular Characteristics, and Microbiological …

H Karch, M Bielaszewska - Journal of Clinical Microbiology, 2001 - Am Soc Microbiol
The significance of Shiga toxin (Stx)-producing Escherichia coli (STEC) O157: H7 as the
major cause of hemorrhagic colitis and the hemolytic-uremic syndrome (HUS) worldwide …

Two copies of Shiga-like toxin II-related genes common in enterohemorrhagic Escherichia coli strains are responsible for the antigenic heterogeneity of the O157: H …

CK Schmitt, ML McKEE, AD O'Brien - Infection and immunity, 1991 - Am Soc Microbiol
Thirty-two clinical isolates of Shiga-like toxin (SLT)-producing Escherichia coli associated
with single cases or outbreaks of bloody diarrhea, hemorrhagic colitis, the hemolytic uremic …

Phage conversion of Panton-Valentine leukocidin in Staphylococcus aureus: molecular analysis of a PVL-converting phage, φSLT

S Narita, J Kaneko, J Chiba, Y Piémont, S Jarraud… - Gene, 2001 - Elsevier
Staphylococcal Panton-Valentine leukocidin (PVL) is an important virulence factor, which
causes leukocytolysis and tissue necrosis. Our previous report on the existence of the PVL …

Detection and characterization of fecal verotoxin-producing Escherichia coli from healthy cattle

MA Montenegro, M Bülte, T Trumpf… - Journal of Clinical …, 1990 - Am Soc Microbiol
Verotoxin-producing Escherichia coli isolates from feces of healthy cattle were identified by
DNA hybridization with verotoxin 1-and verotoxin 2-specific gene probes. Among 259 …

Structural Analysis of Phage-Borne stx Genes and Their Flanking Sequences in Shiga Toxin-Producing Escherichia coli and Shigella dysenteriae Type 1 Strains

A Unkmeir, H Schmidt - Infection and immunity, 2000 - Am Soc Microbiol
The stx-flanking regions of 49 Shiga toxin-producing Escherichia coli strains and nine
Shigella dysenteriae serotype 1 strains containing either stx, stx 1, stx 2, or stx 2 variant …

Stx-phages: drivers and mediators of the evolution of STEC and STEC-like pathogens

HE Allison - 2007 - Future Medicine
Bacteriophages, also known as phages, are viruses that infect bacteria. Until recently they
have been ignored by most of the scientific community, but their impact upon our world is …