[HTML][HTML] Assessing neurogenic lower urinary tract dysfunction after spinal cord injury: Animal models in preclinical neuro-urology research

AW Doelman, F Streijger, SJA Majerus, MS Damaser… - Biomedicines, 2023 - mdpi.com
Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding
function and remains one of the leading causes of morbidity after spinal cord injury (SCI) …

[HTML][HTML] Molecular mechanism operating in animal models of neurogenic detrusor overactivity: A systematic review focusing on bladder dysfunction of neurogenic …

A Ferreira, D Nascimento, CD Cruz - International Journal of Molecular …, 2023 - mdpi.com
Neurogenic detrusor overactivity (NDO) is a severe lower urinary tract disorder,
characterized by urinary urgency, retention, and incontinence, as a result of a neurologic …

[HTML][HTML] Acute ampakines increase voiding function and coordination in a rat model of SCI

S Rana, F Alom, RC Martinez, DD Fuller, AD Mickle - Elife, 2024 - elifesciences.org
Neurogenic bladder dysfunction causes urological complications and reduces the quality of
life in persons with spinal cord injury (SCI). Glutamatergic signaling via AMPA receptors is …

Early transcutaneous tibial nerve stimulation acutely improves lower urinary tract function in spinal cord injured rats

AM Sartori, S Salemi, AS Hofer, V Baumgartner… - Neurotrauma …, 2022 - liebertpub.com
Despite the fact that a majority of patients with an injury to the spinal cord develop lower
urinary tract dysfunction, only few treatment options are available currently once the …

Evolution of magnetic resonance imaging as predictors and correlates of functional outcome after spinal cord contusion injury in the rat

N Wilkins, NP Skinner, A Motovylyak… - Journal of …, 2020 - liebertpub.com
Clinical methods for determining the severity of traumatic spinal cord injury (SCI) and long-
term functional outcome in the acute setting are limited in their prognostic accuracy because …

Small-sample performance and underlying assumptions of a bootstrap-based inference method for a general analysis of covariance model with possibly …

G Zimmermann, M Pauly… - Statistical methods in …, 2019 - journals.sagepub.com
It is well known that the standard F test is severely affected by heteroskedasticity in
unbalanced analysis of covariance models. Currently available potential remedies for such …

Spinal transection alters external urethral sphincter activity during spontaneous voiding in freely moving rats

BK LaPallo, JR Wolpaw, X Yang Chen… - Journal of …, 2017 - liebertpub.com
The rat is a commonly used model for the study of lower urinary tract function before and
after spinal cord injury. We have previously reported that in unanesthetized freely moving …

Serial transurethral cystometry: A novel method for longitudinal evaluation of reflex lower urinary tract function in adult female rats

F Qureshi, P Kung, W Hou, WF Collins III… - Physiological …, 2022 - Wiley Online Library
Aims The aim of the study is to develop a minimally invasive method for longitudinal
evaluation of lower urinary tract function that allows for simultaneous measurements of …

Intrathecal implantation surgical considerations in rodents; a review

A Arman, MR Hutchinson - Journal of Neuroscience Methods, 2021 - Elsevier
Intrathecal access in humans is a routine clinical intervention. However, intrathecal access is
limited to drug delivery purposes in rodents, and intrathecal implantation is not a common …

Validation of a new rat model of urethral sphincter injury and leak point pressure measurements

AS Abdelkhalek, PD Clarke, MA Sommers… - … Journal of Urology, 2021 - Taylor & Francis
Aims In vivo experiments were performed to establish and validate a rat model of urethral
sphincter injury and to develop a method for leak point pressure (LPP) measurements …