Molecular mechanisms of metal toxicity in the pathogenesis of Alzheimer's disease
MT Kabir, MS Uddin, S Zaman, Y Begum… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …
Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress
Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and …
J Wu, MR Basha, B Brock, DP Cox… - Journal of …, 2008 - Soc Neuroscience
The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may
drive AD pathogenesis; however, the triggering factors and the period of their action are …
drive AD pathogenesis; however, the triggering factors and the period of their action are …
New and evolving concepts in the neurotoxicology of lead
LD White, DA Cory-Slechta, ME Gilbert… - Toxicology and applied …, 2007 - Elsevier
Lead (Pb) is a xenobiotic metal with no known essential function in cellular growth,
proliferation, or signaling. Decades of research characterizing the toxicology of Pb have …
proliferation, or signaling. Decades of research characterizing the toxicology of Pb have …
Ligand binding strategies of human serum albumin: how can the cargo be utilized?
Human serum albumin (HSA), being the most abundant carrier protein in blood and a
modern day clinical tool for drug delivery, attracts high attention among biologists. Hence, its …
modern day clinical tool for drug delivery, attracts high attention among biologists. Hence, its …
Epigenetics, oxidative stress, and Alzheimer disease
Alzheimer disease (AD) is a progressive neurodegenerative disorder whose clinical
manifestations appear in old age. The sporadic nature of 90% of AD cases, the differential …
manifestations appear in old age. The sporadic nature of 90% of AD cases, the differential …
DNA damage in neurodegenerative diseases
F Coppedè, L Migliore - Mutation Research/Fundamental and Molecular …, 2015 - Elsevier
Following the observation of increased oxidative DNA damage in nuclear and mitochondrial
DNA extracted from post-mortem brain regions of patients affected by neurodegenerative …
DNA extracted from post-mortem brain regions of patients affected by neurodegenerative …
[HTML][HTML] Doença de Alzheimer: hipóteses etiológicas e perspectivas de tratamento
With the increase in life expectancy registered in the past few decades, the prevalence of
various medical conditions related to aging has been observed, such as dementia and …
various medical conditions related to aging has been observed, such as dementia and …
Metal-organic frameworks: A promising option for the diagnosis and treatment of Alzheimer's disease
Beta-amyloid (Aβ) peptide is one of the main characteristic biomarkers of Alzheimer's
disease (AD). Previous clinical investigations have proposed that unusual concentrations of …
disease (AD). Previous clinical investigations have proposed that unusual concentrations of …
Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics
Several lines of evidence indicate that the etiology of late-onset Alzheimer's disease (LOAD)
is complex, with significant contributions from both genes and environmental factors. Recent …
is complex, with significant contributions from both genes and environmental factors. Recent …