How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the “LEARn” model (latent early-life associated regulation) may …

DK Lahiri, B Maloney, M Riyaz Basha… - Current alzheimer …, 2007 - ingentaconnect.com
Alzheimer's disease (AD) is currently the most prominent form of dementia among the
elderly. Although AD manifests in late adult life, it is not clear when the disease actually …

Tracing the role of plant proteins in the response to metal toxicity: a comprehensive review

S Jain, S Muneer, G Guerriero, S Liu… - Plant signaling & …, 2018 - Taylor & Francis
Plants are sessile in nature, but are capable to evade from high level concentration of heavy
metals like Cd, Hg, Cu, through various metabolic pathways. Some of the pathways regulate …

Clerodendrum viscosum leaves attenuate lead-induced neurotoxicity through upregulation of BDNF-Akt-Nrf2 pathway in mice

J Islam, TT Shila, Z Islam, E Kabir, N Haque… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Clerodendrum viscosum is an important medicinal plant in
Ayurveda in Bangladesh and its leaves are used as a remedy for various diseases such as …

Curcumin Ameliorates Lead (Pb2+)-Induced Hemato-Biochemical Alterations and Renal Oxidative Damage in a Rat Model

AM Abdel-Moneim, MY El-Toweissy, AM Ali… - Biological trace element …, 2015 - Springer
This study aims to evaluate the protective role of curcumin (Curc) against hematological and
biochemical changes, as well as renal pathologies induced by lead acetate [Pb (CH 3 COO) …

Pathogenic mechanisms of heavy metal induced-Alzheimer's disease

HJ Lee, MK Park, YR Seo - Toxicology and Environmental Health …, 2018 - Springer
Alzheimer's disease is an increasing neurodegenerative disease in the aging population.
The disease is associated with toxic chemicals of industrial origin. Industrial processes can …

Prenatal lead (Pb) exposure and peripheral blood DNA methylation (5mC) and hydroxymethylation (5hmC) in Mexican adolescents from the ELEMENT birth cohort

CA Rygiel, JM Goodrich… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Gestational lead (Pb) exposure can adversely affect offspring health through
multiple mechanisms, including epigenomic alterations via DNA methylation (5mC) and …

Aging and oxidatively damaged nuclear DNA in animal organs

P Møller, M Løhr, JK Folkmann, L Mikkelsen… - Free Radical Biology and …, 2010 - Elsevier
Oxidative stress is considered to contribute to aging and is associated with the generation of
oxidatively damaged DNA, including 8-oxo-7, 8-dihydroguanine. We have identified 69 …

Early life exposure to lead (Pb) and changes in DNA methylation: relevance to Alzheimer's disease

SW Bihaqi - Reviews on environmental health, 2019 - degruyter.com
Recent advances in neuroepigenetics have revealed its essential role in governing body
function and disease. Epigenetics regulates an array of mechanisms that are susceptible to …

The chemical exposome of human aging

BB Misra - Frontiers in Genetics, 2020 - frontiersin.org
Aging is an inevitable biological phenomenon displayed by single cells and organs to entire
organismal systems. Aging as a biological process is characterized as a progressive decline …

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase

G Kronenberg, C Harms, RW Sobol… - Journal of …, 2008 - Soc Neuroscience
Folate deficiency and resultant increased homocysteine levels have been linked
experimentally and epidemiologically with neurodegenerative conditions like stroke and …