Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

Substance use disorders are a global health problem with increasing prevalence resulting in
significant socioeconomic burden and increased mortality. Converging lines of evidence …

Sex differences in motivation for food rewards, gambling, and drugs of abuse are modulated
by multiple factors, including sensory stimuli, gonadal hormones, and cognitive bias. Cues …

Contextual triggers are significant factors contributing to relapse in substance use disorders
(SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as …

The medial prefrontal cortex (mPFC) drives cocaine‐seeking behaviour in rodent models of
cocaine use disorder. Parvalbumin (PV)‐containing GABAergic interneurons powerfully …

Perineuronal nets (PNNs) are cartilage-like structures of extracellular matrix molecules that
enwrap in a net-like manner the cell-body and proximal dendrites of special subsets of …

Repeated stress can predispose to substance abuse. However, behavioral and
neurobiological adaptations that link stress to substance abuse remain unclear. This study …

The medial prefrontal cortex (mPFC) is a major contributor to relapse to cocaine in humans
and to reinstatement behavior in rodent models of cocaine use disorder. Output from the …

Objective Perineuronal nets (PNN) are specialized extracellular matrix (ECM) components
of the central nervous system, frequently accumulating at the surface of inhibitory GABAergic …

Often considered the “housekeeping” cells of the brain, astrocytes have of late been rising to
the forefront of neurodegenerative disorder research. Identified as crucial components of a …