Anti-programmed cell death 1 (PD-1) or anti-PD-ligand (L) 1 drugs, as classic immune
checkpoint inhibitors, are considered promising treatment strategies for tumors. In clinical …

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal
tumors (GISTs) which occur throughout the whole gastrointestinal tract, and affect human …

Abstract Bromodomain‐containing 4 (BRD4), a member of Bromo and Extra‐Terminal (BET)
family, recognizes acetylated histones and is of importance in transcription, replication, and …

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the first-line
standard treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutation …

Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in
gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage. Both ICC …

Background Preeclampsia (PE) is a frequently occurring pregnancy disorder in the placenta,
which results in various maternal and fetal complications. The current study aims to evaluate …

Tumor-associated macrophages (TAMs) promote tumor proliferation, invasion,
angiogenesis, stemness, therapeutic resistance, and immune tolerance in a protein …

Simple Summary The current treatment options for medulloblastoma, the most common
malignant childhood brain cancer, are associated with many negative side effects and …

Purpose Radiation therapy (RT) is mainly used for bladder preservation in patients with
muscle-invasive bladder cancer. The response of urothelial tumors to RT remains …