Marine natural products from the Russian Pacific as sources of drugs for neurodegenerative diseases
YS Khotimchenko, DN Silachev, VL Katanaev - Marine Drugs, 2022 - mdpi.com
Neurodegenerative diseases are growing to become one of humanity's biggest health
problems, given the number of individuals affected by them. They cause enough mortalities …
problems, given the number of individuals affected by them. They cause enough mortalities …
Psychopharmacological properties and therapeutic profile of the antidepressant venlafaxine
Major depression (MD) is one of the most common psychiatric disorders worldwide.
Currently, the first-line treatment for MD targets the serotonin system but these drugs, notably …
Currently, the first-line treatment for MD targets the serotonin system but these drugs, notably …
Bioinformatics and network pharmacology identify the therapeutic role and potential mechanism of melatonin in AD and rosacea
H Zhang, Y Zhang, Y Li, Y Wang, S Yan, S Xu… - Frontiers in …, 2021 - frontiersin.org
Rosacea is significantly associated with dementia, particularly Alzheimer's disease (AD).
However, the common underlying molecular mechanism connecting these two diseases …
However, the common underlying molecular mechanism connecting these two diseases …
Soluble biomarkers of cerebrovascular pathologies
KE Foley, DM Wilcock - Stroke, 2024 - Am Heart Assoc
Vascular contributions to cognitive impairment and dementia (VCID) is an all-encompassing
term that describes cognitive impairment due to cerebrovascular origins. With the …
term that describes cognitive impairment due to cerebrovascular origins. With the …
[HTML][HTML] Protective signature of IFNγ-stimulated microglia relies on miR-124-3p regulation from the Secretome released by mutant APP Swedish neuronal cells
Microglia-associated inflammation and miRNA dysregulation are key players in Alzheimer's
disease (AD) pathophysiology. Previously, we showed miR-124 upregulation in APP …
disease (AD) pathophysiology. Previously, we showed miR-124 upregulation in APP …
Enriched environmental exposure reduces the onset of action of the serotonin norepinephrin reuptake inhibitor venlafaxine through its effect on parvalbumin …
B Coutens, C Lejards, G Bouisset, L Verret… - Translational …, 2023 - nature.com
Mood disorders are associated with hypothalamic-pituitary-adrenal axis overactivity
resulting from a decreased inhibitory feedback exerted by the hippocampus on this brain …
resulting from a decreased inhibitory feedback exerted by the hippocampus on this brain …
[HTML][HTML] Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of …
FJ Mirza, S Zahid - Frontiers in pharmacology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder characterized by
substantial neuronal damage which manifests in the form of deficits in memory and …
substantial neuronal damage which manifests in the form of deficits in memory and …
Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence
C Ji, C Wei, M Li, S Shen, S Zhang, Y Hou… - Pharmaceutical …, 2022 - Taylor & Francis
Abstract Context Bazi Bushen capsule (BZBS) has anti-ageing properties and is effective in
enhancing memory. Objective To find evidence supporting the mechanisms and biomarkers …
enhancing memory. Objective To find evidence supporting the mechanisms and biomarkers …
Metal Complexes as Promising Matrix Metalloproteinases Regulators
Nowadays, cancers and dementia, such as Alzheimer's disease, are the most fatal causes of
death. Many studies tried to understand the pathogenesis of those diseases clearly and …
death. Many studies tried to understand the pathogenesis of those diseases clearly and …
Response of circulating inflammatory markers to intermittent hypoxia-hyperoxia training in healthy elderly people and patients with mild cognitive impairment
Intermittent hypoxia-hyperoxia training (IHHT) is a non-pharmacological therapeutic
modality for management of some chronic-and age-related pathologies, such as Alzheimer's …
modality for management of some chronic-and age-related pathologies, such as Alzheimer's …