Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region
leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants …

Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor
that regulates antioxidant response elements (AREs)-mediated expression of antioxidant …

Germ-line GATA2 gene mutations, leading to haploinsufficiency, have been identified in
patients with familial myelodysplastic syndrome/acute myeloid leukemia, monocytopenia …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder in which excessive
deposition of extracellular matrix leads to irreversible scarring of interstitial lung tissue. The …

Hematopoiesis involves an elaborate regulatory network of transcription factors that
coordinates the expression of multiple downstream genes, and maintains homeostasis …

Platelets, derived from megakaryocytes, have an essential role in thrombosis and
hemostasis. Over the past 10 years, a great deal of new information has been obtained …

Allnucleated cellsdepend on heme, an iron-protoporphyrin, fortheirsurvival, asheme
sensesorusesoxygen (Fig. 1). Hemefunctions asaprostheticmoietyofvarioushemoproteins …

Human skin is constantly exposed to UV light, the most ubiquitous environmental stressor.
Here, we investigated the expression and regulation of Nrf1-3, transcription factors crucially …

There are many examples of transcription factor families whose members control gene
expression profiles of diverse cell types. However, the mechanism by which closely related …

Differentiation therapy is an attractive approach aiming at reversing malignancy and
reactivating endogenous differentiation programs in cancer cells. Olive leaf extract, known …