Azide-alkyne cycloaddition reaction is a very common organic reaction to synthesize
nitrogen-containing heterocycles. Once catalyzed by Cu (I) or Ru (II), it turns out to be a click …

Pyrimidines have become an increasingly important core structure in many drug molecules
over the past 60 years. This article surveys recent areas in which pyrimidines have had a …

Ovarian cancer stands as the fifth most prevalent cancer among women, causing more
mortalities than any other disease of the female reproductive system. There are numerous …

Ischemic stroke is a major cause of death and disability worldwide. The poor drug delivery to
cerebral ischemic regions remains a challenging issue for ischemic stroke treatment …

Aurora kinase B (AURKB) is an attractive and potential molecular target for cervical cancer
therapy. To date, a variety of AURKB inhibitors are developed to suppress cervical tumors …

Background Ovarian cancer (OC) is distinguished by its aggressive nature and the limited
efficacy of current treatment strategies. Recent studies have emphasized the significant role …

Salt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑
activated protein kinase family. They are expressed ubiquitously in humans. Under normal …

Rationale: Orbital inflammation is a prevalent and prolonged ocular disease that poses a
significant challenge to clinicians. Glucocorticoid Dexamethasone sodium phosphate (Dex) …

Most existing hydrogels, even recently developed injectable hydrogels that undergo a
reversible sol‒gel phase transition in response to external stimuli, are designed to gel …

Salt-inducible kinases (SIKs) play a crucial role in inflammation process, acting as molecular
switches that regulate the transformation of M1/M2 macrophages. HG-9-91–01 is a SIKs …