Sigma-1 receptors in depression: mechanism and therapeutic development
P Ren, J Wang, N Li, G Li, H Ma, Y Zhao… - Frontiers in …, 2022 - frontiersin.org
Depression is the most common type of neuropsychiatric illness and has increasingly
become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 …
become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 …
Striatal synaptic dysfunction in dystonia and levodopa-induced dyskinesia
M Scarduzio, EJ Hess, DG Standaert… - Neurobiology of …, 2022 - Elsevier
This review provides an overview of the synaptic dysfunctions of neuronal circuits and
underlying neurochemical alterations observed in the hyperkinetic movement disorders …
underlying neurochemical alterations observed in the hyperkinetic movement disorders …
PDE10A inhibitors—clinical failure or window into antipsychotic drug action?
FS Menniti, TA Chappie, CJ Schmidt - Frontiers in Neuroscience, 2021 - frontiersin.org
PDE10A, a phosphodiesterase that inactivates both cAMP and cGMP, is a unique signaling
molecule in being highly and nearly exclusively expressed in striatal medium spiny neurons …
molecule in being highly and nearly exclusively expressed in striatal medium spiny neurons …
Underlying susceptibility to eating disorders and drug abuse: genetic and pharmacological aspects of dopamine D4 receptors
L Botticelli, E Micioni Di Bonaventura, F Del Bello… - Nutrients, 2020 - mdpi.com
The dopamine D4 receptor (DRD4) has a predominant expression in the prefrontal cortex
(PFC), brain area strictly involved in the modulation of reward processes related to both food …
(PFC), brain area strictly involved in the modulation of reward processes related to both food …
Metabolic aspects of adenosine functions in the brain
M Garcia-Gil, M Camici, S Allegrini, R Pesi… - Frontiers in …, 2021 - frontiersin.org
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly,
plays a complex role in multiple physiological and pathophysiological processes by …
plays a complex role in multiple physiological and pathophysiological processes by …
Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial
Acute caffeine intake has been found to increase working memory (WM)-related brain
activity in healthy adults without improving behavioral performances. The impact of daily …
activity in healthy adults without improving behavioral performances. The impact of daily …
[HTML][HTML] Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders
It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …
that a neurocentric perspective of the integrative signal communication in the central …
Serotonin heteroreceptor complexes and their integration of signals in neurons and Astroglia—relevance for mental diseases
DO Borroto-Escuela, P Ambrogini, M Narvaez… - Cells, 2021 - mdpi.com
The heteroreceptor complexes present a novel biological principle for signal integration.
These complexes and their allosteric receptor–receptor interactions are bidirectional and …
These complexes and their allosteric receptor–receptor interactions are bidirectional and …
Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and …
K Prasad, EFJ de Vries, PH Elsinga… - International Journal of …, 2021 - mdpi.com
Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …
Disrupting GPCR complexes with smart drug-like peptides
G protein-coupled receptors (GPCRs) are a superfamily of proteins classically described as
monomeric transmembrane (TM) receptors. However, increasing evidence indicates that …
monomeric transmembrane (TM) receptors. However, increasing evidence indicates that …