Patients with heritable connective tissue disorders (HCTDs), represented by Marfan
syndrome, can develop fatal aortic and/or arterial complications before age 50. Therefore …

Introduction Acute aortic dissection is the most common cause of death in patients with
Marfan syndrome and untreated aortic root enlargement. Emergency surgery for …

Aortic root aneurysm is the most common cardiovascular manifestation requiring surgical
intervention in patients with Marfan syndrome (MFS), a heritable thoracic aortic disease …

Genetic discovery for heritable thoracic aortic disease (HTAD) has been progressing at a
brisk pace. Surgical management of thoracic aortic aneurysms and dissections has become …

Valve-sparing aortic root replacement (VSARR) through reimplantation technique is widely
regarded as optimal surgical approach for Marfan syndrome (MFS) patients. Perioperative …

Prosthetic aortic valve replacements have long been the mainstay of valvular surgery due to
their favorable outcomes and low operative complexity. Yet, mechanical valves require …

Long non‑coding RNAs (lncRNAs) serve a crucial role in every aspect of cell biological
functions as well as in a variety of diseases, including cardiovascular disease, cancer and …

Background A diversity of surgical strategies are used to treat Marfan syndrome patients with
aortic disease. We sought to evaluate the long-term efficiency of aortic root replacement …

Innovative surgical procedures often arise from foundations of knowledge and experiences
with established operations. Aortic valve sparing operation was one of this stepwise …

Aortic valve (AV) preservation and repair is emerging as an attractive alternative to AV
replacement in younger patients with aortic insufficiency (AI) and aortic root aneurysms. AV …