The ABCG5/G8 heterodimer is the primary neutral sterol transporter in hepatobiliary and
transintestinal cholesterol excretion. Inactivating mutations on either the ABCG5 or ABCG8 …

Sitosterolemia is a lipid disorder characterized by the accumulation of dietary xenosterols in
plasma and tissues caused by mutations in either ABCG5 or ABCG8. ABCG5 ABCG8 …

BACKGROUND Gallstones are abnormal stone masses formed in the gallbladder or the
intrahepatic bile ducts and infrequently also migrate to the common bile duct or the …

Objectives The objective of this cohort study was to determine whether subjects with
gallstone disease identified by screening of a general population had increased overall …

Abstract Knowledge about temporal associations for screen-detected gallstone disease and
cardiovascular disease is limited. The objective of this study was to determine if screen …

Background Gallstones are abnormal masses caused by impaired metabolism of
cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette …

ABCG5 and ABCG8 are two key adenosine triphosphate-binding cassette (ABC) proteins
that regulate whole-body sterol trafficking. This study aimed to elucidate the association …

This review addresses the contribution of some genes to the phenotype of familial
hypercholesterolemia. At present, it is known that the pathogenesis of this disease involves …

Cholesterol gallstone disease (CGD) is one of the most common digestive diseases, and it is
closely associated with hepatic cholesterol metabolism. Cholesterol gallstones may be …

Background Gallbladder disease (GBD) can increase the risk of cardiovascular disease
(CVD). However, GBD has rarely been reported in the less developed, rural areas of …