Simple Summary In order for a cell to divide into two cells, it must first copy its DNA. Although
the time required for this process tends not to vary much, many examples of the importance …

Background & Aims Leucine-rich repeat-containing G-protein–coupled receptor-5
(Lgr5)+/olfactomedin-4 (Olfm4)+ intestinal stem cells (ISCs) in the crypt base are crucial for …

Mouse embryonic stem cells (mESCs) can be maintained as homogeneous populations in
the ground state of pluripotency. Release from this state in minimal conditions allows to …

Traumatic brain injury (TBI) is associated with poor clinical outcomes; autopsy studies of TBI
victims demonstrate significant oligodendrocyte progenitor cell (OPC) death post TBI; an …

Tagging proliferating cells with thymidine analogs is an indispensable research tool;
however, the issue of the potential in vivo cytotoxicity of these compounds remains …

Mammalian Müller glia express transcription factors and cell cycle regulators essential for
the function of retinal progenitors, indicating the latent neurogenic capacity; however, the …

Mutations in genes that disrupt centrosome structure or function can cause congenital
kidney developmental defects and lead to fibrocystic pathologies. Yet, it is unclear how …

Root system architecture ultimately depends on precise signaling between different cells
and tissues in the root apical meristem (RAM) and integration with environmental cues. This …

We describe a genome-wide screening strategy to identify target genes whose modulation
increases the capacity of a cell to produce recombinant adeno-associated viral (AAV) vector …

The spermatogonial compartment maintains spermatogenesis throughout the reproductive
lifespan. Single-cell RNA sequencing (scRNA-seq) has revealed the presence of several …