TMED2 is involved in morphogenesis of the mouse embryo and placenta. We found that
expression of TMED2 was higher in epithelial ovarian cancer tissues than normal ovarian …

Berberine is a naturally occurring isoquinoline alkaloid that has great potential as a lead
compound for the development of highly effective anti-cancer agents. In this study, some …

The excessive accumulation of lipids in hepatocytes induces a type of cytotoxicity called
hepatic lipotoxicity, which is a fundamental contributor to liver metabolic diseases (such as …

In vivo, stem cells reside in a three-dimensional (3D) extracellular microenvironment in
which complicated biophysical and biochemical factors regulate their behaviors …

Silibinin is a flavonoid compound extracted from the seeds of Silybum marianum (L.) Gaertn.
It has the functions of liver protection, blood-lipid reduction and anti-tumor effects. However …

Skeletal muscle is the largest tissue of the body and performs multiple functions, from
locomotion to body temperature control. Its functionality and recovery from injuries depend …

Sponges (phylum Porifera) exhibit surprisingly complex tissue dynamics, maintaining
constant cell turnover and migration, rearranging internal structures, and regenerating after …

In human and other metazoans, the determinants of replication origin location and strength
are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle …

Background TBC1 domain family member 24 (TBC1D24) pathogenic mutations affect its
binding to ARF6 and then result in severe impairment of neuronal development. However …

BACKGROUND: Endothelial cells regulate their cell cycle as blood vessels remodel and
transition to quiescence downstream of blood flow–induced mechanotransduction. Laminar …