This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits
contain the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in …

Almost a century ago, in 1901, Eugene L. Opie described “hyaline degeneration of the
islands of Langerhans” in the pancreas of patients with hyperglycemia (Figure 1). 1 A …

Islet amyloid has been recognized as a pathological entity in type 2 diabetes since the turn
of the century. It has as its unique component the islet beta-cell peptide islet amyloid …

Characterized as a peripheral metabolic disorder and a degenerative disease of the central
nervous system respectively, it is now widely recognized that type 2 diabetes mellitus …

Type 2 diabetes is characterized by a progressive loss of beta-cell function throughout the
course of the disease. The pattern of loss is an initial defect in early or first-phase insulin …

Islet amyloid polypeptide (IAPP, amylin) is secreted from pancreatic islet β-cells and
converted to amyloid deposits in type 2 diabetes. Conversion from soluble monomer, IAPP 1 …

A. Peripherally acting agents B. Centrally acting agents IV. Drugs That Alter Metabolism A.
Preabsorptive agents B. Postabsorptive modifiers of nutrient metabolism V. Drugs That …

Pancreatic islet amyloid deposits are a characteristic pathologic feature of non-insulin-
dependent diabetes mellitus and contain islet amyloid polypeptide (IAPP; amylin). We used …