Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates
Background The unmet demand for effective malaria transmission-blocking agents targeting
the transmissible stages of Plasmodium necessitates intensive discovery efforts. In this …
the transmissible stages of Plasmodium necessitates intensive discovery efforts. In this …
Antibiofilm activity and mode of action of DMSO alone and its combination with afatinib against Gram-negative pathogens
Biofilms are complex microbial communities that tend to attach to either biotic or abiotic
surface. Enclosed in a self-produced extracellular polymeric substance (EPS) matrix, the …
surface. Enclosed in a self-produced extracellular polymeric substance (EPS) matrix, the …
[HTML][HTML] Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
Malaria remains one of the most deadly diseases threatening humankind and is still
affecting a significant proportion of the world population, especially in Africa. Chemotherapy …
affecting a significant proportion of the world population, especially in Africa. Chemotherapy …
In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species
Ethnopharmacological relevance: Extracts of plant species, used traditionally to treat
malaria, have been extensively investigated for their activity against Plasmodium …
malaria, have been extensively investigated for their activity against Plasmodium …
Malaria transmission blocking compounds: a patent review
S Consalvi, C Tammaro, F Appetecchia… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Despite substantial progress in the field, malaria remains a global health issue
and currently available control strategies are not sufficient to achieve eradication. Agents …
and currently available control strategies are not sufficient to achieve eradication. Agents …
Liposomes for malaria management: the evolution from 1980 to 2020
PB Memvanga, CI Nkanga - Malaria Journal, 2021 - Springer
Malaria is one of the most prevalent parasitic diseases and the foremost cause of morbidity
in the tropical regions of the world. Strategies for the efficient management of this parasitic …
in the tropical regions of the world. Strategies for the efficient management of this parasitic …
Emerging Drug Targets for Antimalarial Drug Discovery: Validation and Insights into Molecular Mechanisms of Function
Approximately 619,000 malaria deaths were reported in 2021, and resistance to
recommended drugs, including artemisinin-combination therapies (ACTs), threatens malaria …
recommended drugs, including artemisinin-combination therapies (ACTs), threatens malaria …
Novel transmission-blocking antimalarials identified by high-throughput screening of Plasmodium berghei Ookluc
J Calit, JE Araújo, B Deng, K Miura… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Safe and effective malaria transmission-blocking chemotherapeutics would allow a
community-level approach to malaria control and eradication efforts by targeting the …
community-level approach to malaria control and eradication efforts by targeting the …
[HTML][HTML] Identification of β-hematin inhibitors in the MMV Malaria Box
KY Fong, RD Sandlin, DW Wright - International Journal for Parasitology …, 2015 - Elsevier
Abstract The Malaria Box, assembled by the Medicines for Malaria Venture, is a set of 400
structurally diverse, commercially available compounds with demonstrated activity against …
structurally diverse, commercially available compounds with demonstrated activity against …
Long circulatory liposomal maduramicin inhibits the growth of Plasmodium falciparum blood stages in culture and cures murine models of experimental malaria
Malaria continues to be one of the deadliest infectious diseases and a global health
menace. The emergence and spread of drug-resistant strains of malaria parasites have …
menace. The emergence and spread of drug-resistant strains of malaria parasites have …