Inhibitors of VEGF (vascular endothelial growth factor)/VEGFR2 (vascular endothelial growth
factor receptor 2) are commonly used in the clinic, but their beneficial effects are only …

Angiogenesis is defined as the formation of new blood vessels from preexisting vessels and
has been characterized as an essential process for tumor cell proliferation and viability. This …

Circulating tumor cells (CTCs) are shed from solid cancers in the form of single or clustered
cells, and the latter display an extraordinary ability to initiate metastasis. Yet, the biological …

Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment.
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that
are poorly understood. Notably, instead of through the induction of angiogenesis, tumor …

Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function,
but is also an important component of the tumour microenvironment as it alters the …

Angiogenesis is a critical step in the progression of almost all human malignancies and
some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective …

Cholangiocarcinoma (CCA) is a heterogeneous group of neoplasms of the bile ducts and
represents the second most common hepatic cancer after hepatocellular carcinoma; it is sub …

Integrins are transmembrane receptors that have been implicated in the biology of various
human physiological and pathological processes. These molecules facilitate cell …