Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment
and promotes cancer progression and resistance to therapy. Many studies reported the …

Neuroblastoma (NB) is the most common extracranial tumor in children resulting in
substantial morbidity and mortality. A deeper understanding of the NB tumor …

Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …

Angiogenesis, the recruitment of new blood vessels, is a critical process for the growth,
expansion, and metastatic dissemination of developing tumors. Three types of cells make up …

Background Inhibitors targeting VEGF and VEGFR are commonly used in the clinic, but only
a subset of patients could benefit from these inhibitors and the efficacy was limited by …

The one-year and median overall survival (mOS) rates of advanced gastroesophageal
adenocarcinomas (GEA) are∼ 50% and< 12 months, respectively. Baseline spatial and …

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects
ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and …

The discovery of tumor angiogenesis opened a new path in fighting cancer. The approval of
different antiangiogenic agents, most targeting vascular endothelial growth factor (VEGF) …

Strategies to target angiogenesis include inhibition of the vessel-stabilizing properties of
vascular pericytes. Pericyte depletion in early-stage non-hypoxic tumors suppressed …

Angiogenesis assays allow for the evaluation of pro-or anti-angiogenic activity of
endogenous or exogenous factors (stimulus or inhibitors) through investigation of their pro …