Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021 - mdpi.com
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Neuroinflammation: friend and foe for ischemic stroke

RL Jayaraj, S Azimullah, R Beiram, FY Jalal… - Journal of …, 2019 - Springer
Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020 - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

Hemorrhagic transformation in ischemic stroke and the role of inflammation

E Spronk, G Sykes, S Falcione, D Munsterman… - Frontiers in …, 2021 - frontiersin.org
Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

Hippocampal vascular supply and its role in vascular cognitive impairment

AC Johnson - Stroke, 2023 - Am Heart Assoc
The incidence of age-related dementia is increasing as the world population ages and due
to lack of effective treatments for dementia. Vascular contributions to cognitive impairment …

Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke

S Sarvari, F Moakedi, E Hone, JW Simpkins… - Metabolic brain disease, 2020 - Springer
Stroke is the leading cause of disability among adults as well as the 2nd leading cause of
death globally. Ischemic stroke accounts for about 85% of strokes, and currently, tissue …

MicroRNA: an emerging predictive, diagnostic, prognostic and therapeutic strategy in ischaemic stroke

RRA Kadir, M Alwjwaj, U Bayraktutan - Cellular and molecular …, 2022 - Springer
Stroke continues to be the third-leading cause of death and disability worldwide. The limited
availability of diagnostic tools approved therapeutics and biomarkers that help monitor …

Multi-omics research strategies in ischemic stroke: A multidimensional perspective

W Li, C Shao, H Zhou, H Du, H Chen, H Wan… - Ageing Research …, 2022 - Elsevier
Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

Salivary biomarkers of oxidative stress and inflammation in stroke patients: from basic research to clinical practice

M Maciejczyk, M Bielas, A Zalewska… - … Medicine and Cellular …, 2021 - Wiley Online Library
Cerebral stroke is a serious worldwide health problem, as can be seen by the global
epidemic of the disease. In this disorder, when the blood flow is compromised by ruptures or …