Background Dedicator of cytokinesis 8 (DOCK8) deficiency is the main cause of the
autosomal recessive hyper‐IgE syndrome (HIES). We previously reported the selective loss …

Flow cytometry has emerged as a useful technology that has facilitated our understanding of
the human immune system. Primary immune deficiency disorders (PIDDs) are a …

Biallelic mutations in the dedicator of cytokinesis 8 gene (DOCK8) cause a progressive
combined immunodeficiency (CID) characterized by susceptibility to severe viral skin …

Patients with inborn errors of immunity (IEI) are prone to develop infections, either due to a
broad spectrum of pathogens or to only one microbe. Since skin is a major barrier tissue …

REFERENCES 1. Loss G, Apprich S, Waser M, Kneifel W, Genuneit J, Buchele G, et al. The
protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA …

Since the discovery of the genetic basis of DOCK8 immunodeficiency syndrome (DIDS) in
2009, several hundred patients worldwide have been reported, validating and extending the …

Patients with inborn errors of immunity (IEI) can suffer from treatment‐refractory inflammatory
bowel disease (IBD) causing failure to thrive and consequences of long‐term multiple …

Inborn errors of immunity (IEI) are inherited disorders that lead to defects in the development
and/or function of the immune system. The number of disorders that can be treated by …

Both Wiskott-Aldrich syndrome (WAS) and dedicator of cytokinesis 8 (DOCK8) deficiency are
primary immunodeficiency diseases caused by mutations in genes that result in defective …

Abstract Purpose of Review Over the last 13 years, the genetic etiologies have been
determined for multiple conditions causing elevated serum IgE, infection susceptibilities, and …