[HTML][HTML] Osteogenesis imperfecta: current and prospective therapies

M Botor, A Fus-Kujawa, M Uroczynska, KL Stepien… - Biomolecules, 2021 - mdpi.com
Osteogenesis Imperfecta (OI) is a group of connective tissue disorders with a broad range of
phenotypes characterized primarily by bone fragility. The prevalence of OI ranges from …

[HTML][HTML] Current overview of osteogenesis imperfecta

M Deguchi, S Tsuji, D Katsura, K Kasahara, F Kimura… - Medicina, 2021 - mdpi.com
Osteogenesis imperfecta (OI), or brittle bone disease, is a heterogeneous disorder
characterised by bone fragility, multiple fractures, bone deformity, and short stature. OI is a …

[HTML][HTML] Mesenchymal stem cells in the treatment of osteogenesis imperfecta

E Lang, JA Semon - Cell Regeneration, 2023 - Springer
Osteogenesis imperfecta (OI) is a disease caused by mutations in different genes resulting
in mild, severe, or lethal forms. With no cure, researchers have investigated the use of cell …

[HTML][HTML] Bisphosphonates and osteonecrosis of the jaws: Clinical and forensic aspects

D Nogueira, IM Caldas, RJ Dinis-Oliveira - Archives of Oral Biology, 2023 - Elsevier
Objective This manuscript aims to provide a comprehensive review of the current knowledge
in the pathophysiology, diagnosis, prevention, and other relevant forensic and clinical …

[HTML][HTML] Bone fragility and osteoporosis in children and young adults

MM Formosa, MA Christou, O Mäkitie - Journal of Endocrinological …, 2024 - Springer
Osteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly
individuals, especially postmenopausal women, are particularly susceptible to osteoporosis …

Pharmacological options in the treatment of osteogenesis imperfecta: A comprehensive review of clinical and potential alternatives

J Muñoz-Garcia, D Heymann, I Giurgea… - Biochemical …, 2023 - Elsevier
Osteogenesis imperfecta (OI) is a genetically heterogeneous connective tissue disorder
characterized by bone fragility and different extra-skeletal manifestations. The severity of …

[HTML][HTML] Aortopathies: from etiology to the role of arterial stiffness

GB Bonfioli, L Rodella, R Rosati, A Carrozza… - Journal of Clinical …, 2023 - mdpi.com
The aorta and aortic wall have a complex biological system of structural, biochemical,
biomolecular, and hemodynamic elements. Arterial stiffness could be considered a …

Emerging Landscape of Osteogenesis Imperfecta Pathogenesis and Therapeutic Approaches

Y Sun, L Li, J Wang, H Liu, H Wang - ACS Pharmacology & …, 2024 - ACS Publications
Osteogenesis imperfecta (OI) is an uncommon genetic disorder characterized by shortness
of stature, hearing loss, poor bone mass, recurrent fractures, and skeletal abnormalities …

Medication-related osteonecrosis of the jaw (MRONJ): a review of pathogenesis hypothesis and therapy strategies

A Jiang, Z Zhang, X Qiu, Q Guo - Archives of Toxicology, 2024 - Springer
Medication-related osteonecrosis of the jaw (MRONJ), a severe side effect caused by
antiresorptive antiangiogenic medication, particularly bisphosphonates (BPs), has become a …

[HTML][HTML] A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories

H Zhang, T Wang, H Gong, R Jiang, W Zhou, H Sun… - Bone Research, 2023 - nature.com
Subclassification of tumors based on molecular features may facilitate therapeutic choice
and increase the response rate of cancer patients. However, the highly complex cell origin …