Secreted proteins play important roles in mediating various biological processes such as
cell–cell communication, differentiation, migration, and homeostasis at the population or …

Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend
of malignant transformation can be described as a two-phase process, where an initial …

Abstract Background Tumor-associated macrophages (TAMs) are known to promote cancer
progression and metastasis through the release of a variety of cytokines. Phosphatase of …

Both phosphatase of regenerating liver-3 (PRL-3) and tumor-associated macrophages
(TAM) influence cancer progression. Whether PRL-3 plays a critical role in colorectal cancer …

Genomic changes that drive cancer initiation and progression contribute to the co-evolution
of the adjacent stroma. The nature of the stromal reprogramming involves differential DNA …

Allergy is inversely related to glioma risk. To determine whether prediagnostic allergy-
related serum proteins are associated with glioma, we conducted a nested case-control …

There is a widening recognition that cancer cells are products of complex developmental
processes. Carcinogenesis and metastasis formation are increasingly described as systems …

Patient-to-patient variability in breast cancer progression complicates clinical treatment
decisions. Of women undergoing prophylactic mastectomies, many may not have …

Chronic stress can promote tumor growth and progression through immunosuppressive
effects and bi-directional interactions between tumor cells and their microenvironment. β …

Epstein-Barr virus (EBV) reactivation can lead to serious complications in kidney transplant
patients, including post-transplant lymphoproliferative disorder (PTLD). Here, we have …