The cellular barriers are major bottlenecks for bioactive compounds entering into cells to
accomplish their biological functions, which limits their biomedical applications …

Although immunotherapy is relatively effective in treating hematological malignancies, their
efficacy against solid tumors is still suboptimal or even noneffective presently. Compared to …

Therapeutic antibodies that block vascular endothelial growth factor (VEGF) show clinical
benefits in treating nonsmall cell lung cancers (NSCLCs) by inhibiting tumor angiogenesis …

Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …

Particle-based drug delivery systems have shown promising application potential to treat
human diseases; however, an incomplete understanding of their interactions with vascular …

mRNA-based therapeutics are revolutionizing the landscape of medical interventions.
However, the short half-life of mRNA and transient protein expression often limits its …

Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern mRNA
vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the …

In the past 11 years, there has been a surge in studies exploring the regulatory effect of
Traditional Chinese Medicine (TCM) on ferroptosis. However, a significant gap persists in …

Eosinophils are important immune effector cells that affect T cell‐mediated antitumor
immunity. However, the low frequency and restrained activity of eosinophils restricted the …

Protein-based nanoparticles have garnered significant attention in theranostic applications
due to their superior biocompatibility, exceptional biodegradability and ease of functionality …