Nucleic acid aptamers are single-stranded DNA or RNA of 20–100 nucleotides in length that
have attracted substantial scientific interest due to their ability to specifically bind to target …

Spatiotemporal translational regulation plays a key role in determining cell fate and function.
Specifically, in neurons, local translation in dendrites is essential for synaptic plasticity and …

RNA-binding proteins (RBPs) have recently emerged as crucial players in the regulation of
gene expression. The interactions of RBPs with target mRNAs control the levels of gene …

Colorectal cancer (CRC) is one of the most lethal malignances in humans. Hence, it is of
great significance to identify regulatory molecules in CRC progression. Accumulating …

Hypertension is the most common chronic disease. Early diagnosis is helpful for early
medical intervention. The miRNAs and the messenger RNAs (mRNAs) network may be …

Long noncoding RNAs (lncRNAs) are a group of noncoding RNAs with transcript lengths of>
200 nucleotides. Mounting evidence suggests that lncRNAs are closely associated with …

During mRNA transcription, diverse RNA-binding proteins (RBPs) are recruited to RNA
polymerase II (RNAP II) transcription machinery. These RBPs bind to distinct sites of nascent …

The nucleus is a highly organized and dynamic environment where regulation and
coordination of processes such as gene expression and DNA replication are paramount. In …

Determining the RNA binding preferences remains challenging because of the bottleneck of
the binding interactions accompanied by subtle RNA flexibility. Typically, designing RNA …

Intrinsically disordered regions (IDRs) and protein (IDPs) are highly flexible owing to their
lack of well-defined structures. A subset of such proteins interacts with various substrates; …