Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

Hematological malignancies are a highly heterogeneous group of diseases with varied
molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) …

In diffuse large B cell lymphoma (DLBCL), tumors belonging to the ABC but not GCB gene
expression subgroup rely upon chronic active B cell receptor signaling for viability, a …

ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …

Follicular lymphoma (FL) is a B-cell malignancy with a complex tumor microenvironment that
is rich in nonmalignant immune cells. We applied single-cell RNA sequencing to …

Patients with relapsed or refractory large B-cell lymphomas (rrLBCL) can achieve long-term
remission after CD19 chimeric antigen receptor T-cell therapy (CART19). However, more …

Multicellular life requires altruistic cooperation between cells. The adaptive immune system
is a notable exception, wherein germinal center B cells compete vigorously for limiting …

SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM
associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive …

CD24 and its ligand Siglec-10 were described as an innate immune checkpoint in
carcinoma. Here, we investigated this axis in B-cell lymphoma by assessing CD24 …

Simple Summary Artificial intelligence (AI) is a field that combines computer science with
robust datasets to solve problems. AI in medicine uses machine learning and deep learning …