The aim of the study was to develop and optimise drug-in-adhesive (DIA) transdermal patch
of duloxetine HCl for enhanced drug delivery. DIA patch so developed reduced the dose …

We investigated the solubility–permeability interplay using a solubilizer additive under non-
sink conditions. Sodium lauryl sulfate (SLS) was used as a solubilizer additive. The solubility …

The Biopharmaceutical classification system (BCS) classifies the drugs based on their
intrinsic solubility and intestinal permeability. The drugs with good solubility and intestinal …

Novel inhibitors of epidermal growth factor receptor (EGFR) T790M/vascular endothelial
growth factor receptor‐2 (VEGFR‐2) were synthesized based on the iodoquinazoline …

Several studies have demonstrated the presence of aggregates in aqueous cyclodextrin
containing solutions. The presence of guest compounds has been shown to influence this …

This study focuses on the synthesis and characterization of a pH-responsive nanogel system
composed of sodium alginate (NaAlg) and poly (acrylic acid) loaded with ferulic acid. The …

About 70% of pharmaceutical drug candidates are poorly soluble and suffer from low oral
bioavailability. Additionally, a large number of therapeutics are also substrates for P …

Hydrogels have been extensively investigated as a platform for drug delivery. However, their
use for the delivery of hydrophobic drugs has been limited by their incompatibility with …

This study intended to evaluate the effect of cyclodextrins on the apparent solubility and
permeability of lipophilic drugs under physiological conditions and establish in silico model …

The present study reports the effects of two pharmaceutical excipients of differing natures—
non-ionic surfactant pluronic F127 (F127) and anionic sulfobutylether-β-cyclodextrin (SBE-β …