Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …

During embryonic development, hierarchical cascades of transcription factors interact with
lineage-specific chromatin structures to control the sequential steps in the differentiation of …

The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …

Adeno-associated virus (AAV) has been successfully used to deliver gene therapy to
improve auditory function in mouse models of hereditary hearing loss. Many forms of …

Hearing loss is a chronic disease affecting millions of people worldwide, yet no restorative
treatment options are available. Although non-mammalian species can regenerate their …

Mammalian cochlear outer hair cells (OHCs) are essential for hearing. Severe hearing
impairment follows OHC degeneration. Previous attempts at regenerating new OHCs from …

Despite a prevalence greater than cancer or diabetes, there are no currently approved drugs
for the treatment of hearing loss. Research over the past two decades has led to a vastly …

Current estimates suggest that nearly half a billion people worldwide are affected by hearing
loss. Because of the major psychological, social, economic, and health ramifications …

Atoh1 is essential for the development of both outer hair cells (OHCs) and inner hair cells
(IHCs) in the mammalian cochlea. Whereas Ikzf2 is necessary for OHC development, the …