Introduction White matter hyperintensities (WMH) are often described in Alzheimer's disease
(AD), but their topography and specific relationships with cognition remain unclear. Methods …

Background Excessive blood glucose promotes neuropathological cognitive decline in
individuals with type 2 diabetes mellitus and the metabolic syndrome, but no systematic …

Background Intranasally administered insulin has shown promise in both rodent and human
studies in Alzheimer's disease; however, both effects and mechanisms require elucidation …

Background White matter hyperintensities (WMH) are frequently found in Alzheimer's
disease (AD). Commonly considered as a marker of cerebrovascular disease, regional …

Emerging evidence indicates that vascular stress is an important contributor to the
pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide …

Cerebral small vessel disease (CSVD) results in a spectrum of neurologic, behavioral, and
cognitive sequelae, most commonly from white matter hyperintensities (WMH) of presumed …

It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ)
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …

Background and purpose Our objective was to apply multi-compartment T2 relaxometry in
cognitively normal individuals aged 20–80 years to study the effect of aging on the …

Including apolipoprotein E-ε4 (APOE-ε4) status and older age into consideration may
increase the accuracy of plasma Aβ42/Aβ40 detecting Aβ+ individuals, but the rationale …

Background and Objectives Physical activity has been associated with a decreased risk for
dementia, but the mechanisms underlying this association remain to be determined. Our …