[HTML][HTML] Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease

A Sobue, O Komine, K Yamanaka - Inflammation and Regeneration, 2023 - Springer
Alzheimer's disease (AD) is the most common form of dementia, pathologically
characterized by senile plaques and neurofibrillary tangles (NFTs), resulting in …

Anatomy and white-matter connections of the precuneus

O Tanglay, IM Young, NB Dadario, RG Briggs… - Brain imaging and …, 2022 - Springer
Purpose Advances in neuroimaging have provided an understanding of the
precuneus'(PCu) involvement in functions such as visuospatial processing and cognition …

[HTML][HTML] Energy crisis links to autophagy and ferroptosis in alzheimer's disease: current evidence and future avenues

DL He, YG Fan, ZY Wang - Current Neuropharmacology, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases
worldwide. The occult nature of the onset and the uncertainty of the etiology largely impede …

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

MP Cadiz, KA Gibson, KT Todd, DG Nascari… - Journal of Experimental …, 2024 - rupress.org
Aducanumab, an anti-amyloid immunotherapy for Alzheimer's disease, efficiently reduces
Aβ, though its plaque clearance mechanisms, long-term effects, and effects of …

[HTML][HTML] Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional …

C Ortiz, A Pearson, R McCartan, S Roche… - Journal of …, 2024 - ncbi.nlm.nih.gov
Epidemiological studies have unveiled a robust link between exposure to repetitive mild
traumatic brain injury (r-mTBI) and elevated susceptibility to develop neurodegenerative …

Telomeric alterations in the default mode network during the progression of Alzheimer's disease: Selective vulnerability of the precuneus

LJ Mahady, B He, M Malek‐Ahmadi… - Neuropathology and …, 2021 - Wiley Online Library
Aims Although telomere length (TL) and telomere maintenance proteins (shelterins) are
markers of cellular senescence and peripheral blood biomarkers of Alzheimer's disease …

[HTML][HTML] Targeting Calpain-2 for Alzheimer's Disease Treatment

AFT Arnsten, M Baudry - Medical Research Archives, 2023 - esmed.org
There is an urgent need for treatments for sporadic Alzheimer's Disease (sAD). Although
antibodies removing ß-amyloid have recently been shown to slow disease progression, the …