There are many cyclic peptides with diverse biological activities, such as antibacterial
activity, immunosuppressive activity, and anti-tumor activity, and so on. Encouraged by …

The folded 3D structures of peptides and proteins provide excellent starting points for the
design of synthetic molecules that mimic key epitopes (or surface patches) involved in …

While an essential role of HIV-1 integrase (IN) for integration of viral cDNA into human
chromosome is established, studies with IN mutants and allosteric IN inhibitors (ALLINIs) …

The interaction of the HIV-1 transactivator protein Tat with its transactivation response (TAR)
RNA is an essential step in viral replication and therefore an attractive target for developing …

RNA drug targets are pervasive in cells, but methods to design small molecules that target
them are sparse. Herein, we report a general approach to score the affinity and selectivity of …

Rapid progress in genome sequencing technology has put us firmly into a postgenomic era.
A key challenge in biomedical research is harnessing genome sequence to fulfill the …

Using a biologically relevant peptide or protein structure as a starting point for lead
identification represents one of the most powerful approaches in modern drug discovery …

The HIV-1 trans-activator protein Tat binds the trans-activation response element (TAR) to
facilitate recruitment of the super elongation complex (SEC) to enhance transcription of the …

The RNA response element TAR plays a critical role in HIV replication by providing a
binding site for the recruitment of the viral transactivator protein Tat. Using a structure-guided …

RNA is an immensely important target for small molecule therapeutics or chemical probes of
function. However, methods that identify, annotate, and optimize RNA-small molecule …