[HTML][HTML] Cancer neuroscience: State of the field, emerging directions
The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …
during development, maintaining homeostasis, and promoting plasticity throughout life, the …
Diffuse glioma heterogeneity and its therapeutic implications
JG Nicholson, HA Fine - Cancer discovery, 2021 - AACR
Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …
characterized by minimally effective genotype-targeted therapies. Recent advances have …
[HTML][HTML] Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
The roles of histone variants in fine-tuning chromatin organization and function
S Martire, LA Banaszynski - Nature reviews Molecular cell biology, 2020 - nature.com
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …
post-translational modification and chromatin remodelling complexes, histone variants …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
[HTML][HTML] The glioma stem cell model in the era of single-cell genomics
Glioma stem cells (GSCs) are thought to underlie glioma initiation, evolution, and resistance
to existing therapies. Although functional evidence for GSCs is abundant, tumor …
to existing therapies. Although functional evidence for GSCs is abundant, tumor …
[HTML][HTML] H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2
SU Jain, AQ Rashoff, SD Krabbenhoft, D Hoelper… - Molecular Cell, 2020 - cell.com
Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent
histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67) …
histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67) …
[HTML][HTML] A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones
that do not readily lend themselves to drug development. To identify druggable targets for …
that do not readily lend themselves to drug development. To identify druggable targets for …
BAF complex maintains glioma stem cells in pediatric H3K27M glioma
Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are
refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of …
refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of …