The phosphatidylinositol 3–kinase (PI3K) signaling pathway is involved in a broad range of
cellular processes, including growth, metabolism, differentiation, proliferation, motility, and …

Primary immunodeficiencies (PIDs) provide researchers with unique models to understand
in vivo immune responses in general and immunity to infections in particular. In humans …

Activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) is an inborn error of
immunity with clinical manifestations including infections, lymphoproliferation, autoimmunity …

Infection of T cells by Epstein-Barr virus (EBV) causes chronic active EBV infection (CAEBV)
characterized by T cell lymphoproliferative disorders (T-LPD) of unclear etiology. Here, we …

Abstract Phosphatidylinositol 3-kinase-gamma (PI3Kγ) is highly expressed in leukocytes
and is an attractive drug target for immune modulation. Different experimental systems have …

Background Germline gain-of function (GOF) mutations in PIK3CD, encoding the catalytic
p110δ subunit of phosphoinositide 3-kinase (PI3K), result in hyperactivation of the PI3K …

The phosphoinositide 3-kinase (PI3K) pathway regulates diverse cellular processes, with
finely tuned PI3Kδ activity being crucial for immune cell development and function. Genetic …

Activated phosphoinositide 3-kinase delta syndrome 1 (APDS-1) is a recently described
inborn error of immunity caused by monoallelic gain-of-function mutations in the PIK3CD …

Common variable immunodeficiency (CVID) represents the largest group of primary
immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and …

Activated PI3K-kinase Delta Syndrome (APDS) is an autosomal-dominant primary
immunodeficiency (PID) caused by the constitutive activation of the PI3Kδ kinase. The …