Recent studies suggest that in humans, DNA sequences responsible for protein coding
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …

The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …

Recent improvements in experimental and computational techniques that are used to study
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …

Background Somatic mutations affecting components of the RNA splicing machinery occur
with high frequencies across many tumor types. These mutations give rise to distinct …

A recent massive parallel sequencing analysis has shown the fact that more than 80% of the
human genome is transcribed into RNA. Among many kinds of the non-protein coding …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

The role of dysregulation of mRNA alternative splicing (AS) in the development and
progression of solid tumors remains to be defined. Here we describe the first comprehensive …

The Polycomb protein enhancer of zeste homolog 2 (EZH2) is frequently overexpressed in
advanced human prostate cancer (PCa), especially in lethal castration-resistant prostate …

Majority of the human genome is transcribed into RNAs with absent or limited protein-coding
potential. microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two major families …

Long noncoding RNAs (lncRNAs) are emerging as a class of important regulators
participating in various biological functions and disease processes. With the widespread …