The long noncoding RNA Malat1: Its physiological and pathophysiological functions
Recent studies suggest that in humans, DNA sequences responsible for protein coding
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches
The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …
molecular biology assuming protein-coding genes as unique functional biological effectors …
Lessons from non-canonical splicing
Recent improvements in experimental and computational techniques that are used to study
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …
Widespread intron retention diversifies most cancer transcriptomes
H Dvinge, RK Bradley - Genome medicine, 2015 - Springer
Background Somatic mutations affecting components of the RNA splicing machinery occur
with high frequencies across many tumor types. These mutations give rise to distinct …
with high frequencies across many tumor types. These mutations give rise to distinct …
MALAT1 long non-coding RNA in cancer
R Yoshimoto, A Mayeda, M Yoshida… - Biochimica et biophysica …, 2016 - Elsevier
A recent massive parallel sequencing analysis has shown the fact that more than 80% of the
human genome is transcribed into RNA. Among many kinds of the non-protein coding …
human genome is transcribed into RNA. Among many kinds of the non-protein coding …
[HTML][HTML] Understanding and targeting prostate cancer cell heterogeneity and plasticity
DG Tang - Seminars in cancer biology, 2022 - Elsevier
Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …
tumors in different patients manifest significant inter-patient heterogeneity with respect to …
Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer
The role of dysregulation of mRNA alternative splicing (AS) in the development and
progression of solid tumors remains to be defined. Here we describe the first comprehensive …
progression of solid tumors remains to be defined. Here we describe the first comprehensive …
[HTML][HTML] LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer
The Polycomb protein enhancer of zeste homolog 2 (EZH2) is frequently overexpressed in
advanced human prostate cancer (PCa), especially in lethal castration-resistant prostate …
advanced human prostate cancer (PCa), especially in lethal castration-resistant prostate …
MicroRNAs, long noncoding RNAs, and their functions in human disease
M Xue, Y Zhuo, B Shan - Bioinformatics in MicroRNA Research, 2017 - Springer
Majority of the human genome is transcribed into RNAs with absent or limited protein-coding
potential. microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two major families …
potential. microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two major families …
A comprehensive overview of lncRNA annotation resources
Long noncoding RNAs (lncRNAs) are emerging as a class of important regulators
participating in various biological functions and disease processes. With the widespread …
participating in various biological functions and disease processes. With the widespread …